吸烟——红细胞增多症的一个主要病因。
Smoking--a major cause of polycythaemia.
作者信息
Aitchison R, Russell N
机构信息
Haematology Department, City Hospital, Nottingham.
出版信息
J R Soc Med. 1988 Feb;81(2):89-91. doi: 10.1177/014107688808100212.
The importance of smoking in the aetiology of polycythaemia has been assessed in a group of patients referred to a general haematology clinic. All patients with true and relative polycythaemia (excluding those with polycythaemia rubra vera) were studied. Of the 21 such patients evaluated, 14 were smokers and had raised carboxyhaemoglobin levels and had no other demonstrable cause for their polycythaemia. The commonest physiological abnormality in these patients was a raised red cell mass combined with a low plasma volume. Six of the 14 patients were able to reduce their smoking with subsequent improvement in their haematocrits. These results suggest that smoking is a major cause of polycythaemia in an unselected series of referrals to a general haematology clinic. The early identification of these patients may be useful in planning therapy.
在一组转诊至普通血液科门诊的患者中，已对吸烟在真性红细胞增多症病因学中的重要性进行了评估。对所有真性和相对性红细胞增多症患者（不包括真性红细胞增多症患者）进行了研究。在评估的21例此类患者中，14例为吸烟者，其碳氧血红蛋白水平升高，且其红细胞增多症无其他可证实的病因。这些患者最常见的生理异常是红细胞量增加合并血浆量减少。14例患者中有6例能够减少吸烟，随后其血细胞比容有所改善。这些结果表明，在未经过挑选的转诊至普通血液科门诊的患者系列中，吸烟是红细胞增多症的主要原因。尽早识别这些患者可能有助于制定治疗方案。
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