Smedley F, Hickish T, Taube M, Yale C, Leach R, Wastell C
Surgical Unit, St Stephen's Hospital, London.
J R Soc Med. 1988 Feb;81(2):92-4. doi: 10.1177/014107688808100214.
Whilst the association between smoking and peptic ulceration has been reported previously, the relationship between smoking and the complications of ulcers, such as perforation, bleeding or acute painful exacerbation, has not been examined. In a retrospective study comparing 275 emergency admissions for peptic ulcer with 275 controls, cigarette smoking was significantly more common only in those with a perforated duodenal ulcer. Of 128 patients with perforated duodenal ulcers, 110 (86%) were cigarette smokers compared with 65 (51%) of the 128 matched controls (X2, P less than 0.01). Cigarette smoking in patients with bleeding or acutely exacerbated ulcers was not significantly more common than in controls. These findings strongly suggest a particular association between smoking and perforated duodenal ulcer.
虽然之前已有报道称吸烟与消化性溃疡之间存在关联，但吸烟与溃疡并发症（如穿孔、出血或急性疼痛加剧）之间的关系尚未得到研究。在一项回顾性研究中，将275例因消化性溃疡而急诊入院的患者与275例对照进行比较，结果发现仅在十二指肠溃疡穿孔患者中吸烟显著更为常见。在128例十二指肠溃疡穿孔患者中，110例（86%）为吸烟者，而128例匹配对照中有65例（51%）吸烟（X²检验，P<0.01）。出血性或急性加重性溃疡患者的吸烟情况与对照组相比并无显著差异。这些发现有力地表明吸烟与十二指肠溃疡穿孔之间存在特定关联。
