Lv Wenyi, Feng Jin, Chen Li, Liu Shuai, Qiu Xiaoguang
Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, People's Republic of China.
Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, People's Republic of China.
Neuropsychiatr Dis Treat. 2021 Jan 14;17:91-98. doi: 10.2147/NDT.S287438. eCollection 2021.
Basal ganglia intracranial germ cell tumors (iGCTs) can specifically destroy the basal ganglia network, leading to several cognitive, learning, behavioral, and social impairments. This study aimed to investigate the behavior and social disorders of patients with basal ganglia iGCTs.
We recruited 30 newly diagnosed iGCTs patients (and their parents) for the current study. The Child Behavior Checklist/6-18 was used to evaluate emotional and behavioral problems. The Conner's Parent Rating Scales was used to assess symptoms of hyperactivity/impulsivity and conduct problems. The health-related quality of life (HRQoL) was assessed using the Pediatric Quality of Life Inventory 4.0 Generic Core Scale. Performance status was assessed using the Lansky play-performance scale and Karnofsky performance scale. The effects of basal ganglia lesions on these scores were examined.
Patients with basal ganglia iGCTs (n = 10) had more behavioral problems (attention problems, aggressive behavior, learning problems, hyperactivity index), social function impairment, anxiety/depression, and poorer HRQoL compared to patients with non-basal ganglia iGCTs (n = 20). There was no significant difference in the Lansky play-performance/Karnofsky performance scale scores.
This study demonstrates the effects of basal ganglia lesions on behavioral and emotional outcomes, social functions, and HRQoL of patients with iGCTs. The results may help to understand the function of basal ganglia and provide evidence for the benefit of early psychological intervention to improve the treatment for this rare disease.
基底节区颅内生殖细胞肿瘤（iGCTs）可特异性破坏基底节网络，导致多种认知、学习、行为和社交障碍。本研究旨在调查基底节区iGCTs患者的行为和社交障碍。
我们招募了30例新诊断的iGCTs患者（及其父母）进行本研究。使用儿童行为量表/6 - 18评估情绪和行为问题。使用康纳斯父母评定量表评估多动/冲动症状和行为问题。使用儿童生活质量量表4.0通用核心量表评估健康相关生活质量（HRQoL）。使用兰斯基游戏表现量表和卡诺夫斯基表现量表评估功能状态。研究基底节病变对这些评分的影响。
与非基底节区iGCTs患者（n = 20）相比，基底节区iGCTs患者（n = 10）存在更多行为问题（注意力问题、攻击行为、学习问题、多动指数）、社交功能障碍、焦虑/抑郁，且HRQoL较差。兰斯基游戏表现量表/卡诺夫斯基表现量表评分无显著差异。
本研究证明了基底节病变对iGCTs患者的行为和情绪结果、社交功能及HRQoL的影响。研究结果可能有助于了解基底节的功能，并为早期心理干预的益处提供证据，以改善这种罕见疾病的治疗。
