Golubjatnikov R, Koehler J E, Buccowich J
Health Lab Sci. 1977 Oct;14(4):284-90.
The results of antistreptolysin O (ASO), antideoxyribonuclease B (ADB), and a multienzyme test, Streptozyme, with 162 sera from a stratified random sample of Wisconsin school children, and specimens routinely submitted for serodiagnosis of Group A streptococcal infections are described. A review of the results of Streptozyme tests of laboratories participating in the State Division of Health Proficiency Testing Program, is also presented. The results of these various tests have revealed both false positive and false negative results with the Streptozyme procedure. Although there was good correlation of the Streptozyme findings with the ASO and ADB tests results with sera from young children, false positive Streptozyme test results increased with age of the study subjects. Our results with the ADB test on sera from apparently normal Wisconsin children and young adults suggest that the upper limits of normal ADB values, suggested by the manufacturers of commercial ADB test kits, may be too low.
本文描述了对来自威斯康星州学龄儿童分层随机样本的162份血清进行抗链球菌溶血素O（ASO）、抗脱氧核糖核酸酶B（ADB）以及多酶检测（链球菌酶试验）的结果，以及常规提交用于A组链球菌感染血清学诊断的标本检测结果。同时还介绍了参与州卫生能力测试项目的实验室进行链球菌酶试验的结果回顾。这些不同检测的结果显示，链球菌酶检测程序存在假阳性和假阴性结果。尽管链球菌酶检测结果与幼儿血清的ASO和ADB检测结果有良好的相关性，但随着研究对象年龄的增长，链球菌酶检测的假阳性结果有所增加。我们对威斯康星州明显正常的儿童和年轻人血清进行ADB检测的结果表明，商业ADB检测试剂盒制造商建议的正常ADB值上限可能过低。
