Hospital Ángeles del Pedregal, Mexico City, Mexico.
Musculoskeletal Ultrasound Laboratory, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico.
Lupus. 2021 Apr;30(4):608-614. doi: 10.1177/0961203320988609. Epub 2021 Jan 20.
To characterize the ultrasound findings of the nail plate and nail bed in systemic lupus erythematosus (SLE) and its association with nail dystrophy.
Thirty-two SLE patients, 36 patients with osteoarthritis (OA) and 20 healthy individuals were studied. High-frequency linear ultrasound was performed in nails of the second to fifth fingers in all participants. Disease activity (SLEDAI-2K index), accrued organ damage (SLICC/ACR index), autoantibody profile, and Raynaud's phenomenon were also assessed in SLE patients.
Nail bed thickness in SLE patients was higher than in healthy individuals (1.25 ± 0.31 mm vs 1.17 ± 0.29 mm; P = 0.01) but lower than in OA (1.39 ± 0.37 mm; P < 0.001), while nail plate thickness was similar among groups. Nail dystrophy was found more frequently in SLE and OA than in healthy individuals. SLE patients with nail dystrophy were older than their counterparts with no dystrophy (39.4 ± 10.4 years vs 27.8 ± 5.6 years; P = 0.004), although nail dystrophy showed no association with SLICC/ACR, SLEDAI-2K, nail bed vascularity, or autoantibodies.
Nail bed in SLE patients is thicker than in healthy individuals but thinner than in OA patients. Nail dystrophy in SLE is associated with advanced age, but not with accrued organ damage, disease activity, Raynaud's phenomenon, or DIP synovitis assessed by ultrasound.
描述系统性红斑狼疮（SLE）患者甲床和甲板的超声表现及其与甲营养不良的关系。
研究纳入 32 例 SLE 患者、36 例骨关节炎（OA）患者和 20 名健康对照者。所有参与者的第二至第五指指甲均行高频线性超声检查。SLE 患者还评估了疾病活动度（SLEDAI-2K 指数）、累积器官损伤（SLICC/ACR 指数）、自身抗体谱和雷诺现象。
SLE 患者的甲床厚度高于健康对照者（1.25±0.31mm 比 1.17±0.29mm；P=0.01），但低于 OA 患者（1.39±0.37mm；P<0.001），而甲板厚度在各组间相似。SLE 和 OA 患者中甲营养不良的发生率均高于健康对照者。SLE 患者中伴有甲营养不良者较无甲营养不良者年龄更大（39.4±10.4 岁比 27.8±5.6 岁；P=0.004），但甲营养不良与 SLICC/ACR、SLEDAI-2K、甲床血管化或自身抗体均无相关性。
SLE 患者的甲床比健康对照者厚，但比 OA 患者薄。SLE 中的甲营养不良与年龄较大有关，但与累积器官损伤、疾病活动度、雷诺现象或超声评估的 DIP 滑膜炎无关。
