The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Department of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Adv Healthc Mater. 2021 Aug;10(15):e2002031. doi: 10.1002/adhm.202002031. Epub 2021 Jan 20.
Gold nanocages (AuNCs) have emerged as a novel class of multifunctional nanomaterials with an array of applications in nanomedicine, including drug delivery, controlled release, as well as disease diagnosis and treatment. Labeling AuNCs with radionuclides not only offers additional therapeutic capabilities but also makes it easy to analyze their biodistribution, monitor their uptake by the tissue or organ of interest, and optimize their performance in both diagnosis and treatment. Here, an introduction to the chemical synthesis and optical properties of AuNCs is provided in the beginning. The methods developed for their radiolabeling are then showcased, followed by the use of radiolabeled AuNCs in tracking and quantifying their pharmacokinetics, including biodistribution, tumor uptake, and intratumoral distribution. Finally, their potential applications in targeted imaging and image-guided therapy are discussed.
金纳米笼(AuNCs)作为一类新型多功能纳米材料,在纳米医学领域有着广泛的应用,包括药物输送、控制释放,以及疾病诊断和治疗。放射性核素标记 AuNCs 不仅提供了额外的治疗能力,而且还可以方便地分析它们的生物分布,监测它们被感兴趣的组织或器官摄取,并优化它们在诊断和治疗中的性能。在这里,首先介绍了 AuNCs 的化学合成和光学性质。然后展示了它们的放射性标记方法,接着讨论了放射性标记的 AuNCs 在跟踪和量化其药代动力学方面的应用,包括生物分布、肿瘤摄取和肿瘤内分布。最后,讨论了它们在靶向成像和图像引导治疗中的潜在应用。