Sorenson D K, Kelly T M, Murray D K, Nelson D H
Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.
J Steroid Biochem. 1988 Feb;29(2):271-3. doi: 10.1016/0022-4731(88)90276-2.
A corticosteroid induced increase in a circulating inhibitor of serum phospholipase A2 activity is described. Inhibitor activity was found to be normally present in serum in agreement with the findings of other workers, and this activity was significantly increased by either acute or chronic administration of corticosteroids. The possible relation of this inhibitor to the known inhibitory effects of lipocortin and sphingomyelin on phospholipase A2 activity is briefly discussed.
本文描述了皮质类固醇诱导血清中磷脂酶A2活性循环抑制剂增加的现象。与其他研究者的发现一致，血清中通常存在抑制剂活性，并且急性或慢性给予皮质类固醇后，这种活性会显著增加。本文简要讨论了这种抑制剂与已知的脂皮质素和鞘磷脂对磷脂酶A2活性的抑制作用之间的可能关系。
