Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.
Department of Optical Science and Engineering, Shanghai Engineering Research Center of Ultra-precision Optical Manufacturing, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Green Photoelectron Platform, Fudan University, Shanghai, P.R. China.
J Perinat Med. 2020 Nov 23;49(2):237-240. doi: 10.1515/jpm-2020-0409. Print 2021 Feb 23.
The coronavirus disease 2019 (COVID-19) had become a worldwide pandemic, however, information is limited on the asymptomatic proportion and thromboembolism risk of pregnant women with infection.
All 32 pregnant women with COVID-19 who were admitted to the hospital in Wuhan during the outbreak from January 20 to March 18, 2020, were retrospectively reviewed for the clinical records, laboratory tests, chest CT scans, and neonatal outcomes.
There were 17 of the 32 patients (53%) with no subjective symptoms before admission, and 13 (41%) remained asymptomatic throughout hospitalization. There were 28 patients (88%) showing typical radiographic evidence of pneumonia on chest CT. The patients with COVID-19 were found in an increased risk of thromboembolism with much higher D-dimer levels than uninfected pregnant women. One neonate with asphyxia and positive immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies was reported.
The considerable asymptomatic proportion of pregnant women with COVID-19 indicates symptom-based screening would miss a number of cases. Chest CT could provide a useful screening resource during the COVID-19epidemic outbreak. Anticoagulation therapy for the postpartum patients may be helpful for good prognosis. The findings provide important information for the hospital isolation, control strategies and clinical therapy.
2019 年冠状病毒病（COVID-19）已在全球范围内流行，但关于感染孕妇的无症状比例和血栓栓塞风险的信息有限。
回顾性分析 2020 年 1 月 20 日至 3 月 18 日期间在武汉住院的 32 例 COVID-19 孕妇的临床记录、实验室检查、胸部 CT 扫描和新生儿结局。
32 例患者中有 17 例（53%）在入院前无主观症状，13 例（41%）在整个住院期间均无症状。28 例（88%）患者胸部 CT 显示典型肺炎放射学证据。COVID-19 患者存在血栓栓塞风险增加，D-二聚体水平明显高于未感染孕妇。报告了 1 例有窒息症状且免疫球蛋白 M（IgM）和免疫球蛋白 G（IgG）抗体阳性的新生儿。
COVID-19 孕妇无症状比例相当高，表明基于症状的筛查会遗漏一部分病例。胸部 CT 可在 COVID-19 疫情爆发期间提供有用的筛查资源。对产后患者进行抗凝治疗可能有助于改善预后。这些发现为医院隔离、控制策略和临床治疗提供了重要信息。
