Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey; Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Endocr Pract. 2020 Oct;26(10):1062-1069. doi: 10.4158/EP-2020-0046.
Subacute thyroiditis (SAT) is an inflammatory thyroid disease that manifests with severe pain. The presence of the vitamin D receptor in immune system cells shows that vitamin D deficiency can trigger inflammatory diseases. The aim of the present study was to determine the prevalence of vitamin D deficiency in SAT patients, and the relationship between vitamin D level and permanent hypothyroidism and recurrence rate.
In this retrospective study, 25-hydroxyvitamin D (25[OH]D) levels of 170 SAT patients and 86 control subjects were compared.
The 25(OH)D levels were significantly lower in the SAT patients, and there was no seasonal difference. A negative correlation was determined between the erythrocyte sedimentation rate and 25(OH)D, but no significant relationship was found between vitamin D level and prognosis.
As a result of this study, it was shown that vitamin D levels in subacute thyroiditis patients were significantly lower than in the healthy control group. Although there is no relationship between vitamin D level and disease prognosis, vitamin D deficiency may increase the rate of respiratory tract infections (especially, influenza, coxsackievirus, measles, adenovirus, retroviruses) and eventually SAT development.
亚急性甲状腺炎（SAT）是一种炎症性甲状腺疾病，表现为剧烈疼痛。维生素 D 受体存在于免疫系统细胞中，表明维生素 D 缺乏会引发炎症性疾病。本研究旨在确定 SAT 患者维生素 D 缺乏的患病率，以及维生素 D 水平与永久性甲状腺功能减退和复发率之间的关系。
在这项回顾性研究中，比较了 170 例 SAT 患者和 86 例对照者的 25-羟维生素 D（25[OH]D）水平。
SAT 患者的 25（OH）D 水平明显较低，且无季节性差异。红细胞沉降率与 25（OH）D 呈负相关，但维生素 D 水平与预后无显著关系。
由于本研究的结果表明，亚急性甲状腺炎患者的维生素 D 水平明显低于健康对照组。尽管维生素 D 水平与疾病预后之间没有关系，但维生素 D 缺乏可能会增加呼吸道感染的发生率（尤其是流感、柯萨奇病毒、麻疹、腺病毒、逆转录病毒），最终导致 SAT 的发生。
