实验精准医学平台：扩展 BXD 小鼠家族。
A platform for experimental precision medicine: The extended BXD mouse family.
机构信息
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Lebenswissenschaftliche Fakultät, Albrecht Daniel Thaer-Institut, Humboldt-Universität zu Berlin, Invalidenstraße 42, 10115 Berlin, Germany.
出版信息
Cell Syst. 2021 Mar 17;12(3):235-247.e9. doi: 10.1016/j.cels.2020.12.002. Epub 2021 Jan 19.
Abstract
The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.
摘要
精准医学的挑战在于对 DNA 变异、表型、发育、环境和治疗之间的复杂相互作用进行建模。我们通过将 BXD 小鼠家族扩展到 140 个完全同基因品系来应对这一挑战，为精准医学创建了一个独特而强大的模型。该家族分离出 600 万个常见 DNA 变异——这一水平超过了许多人类群体。由于每个成员都可以被复制，因此可以以高精度和高精准度对可遗传特征进行映射。目前的 BXD 表型在涵盖范围方面是无与伦比的，包括大量的组学数据和数千个定量特征。BXDs 可以通过一代杂交扩展到多达 19460 个同基因 F1 后代，而这个扩展的 BXD 家族是测试因果建模和预测验证的有效平台。BXDs 是实验精准医学领域的独特核心资源。
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