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新型光动力材料 TPE-IQ-2O 在肿瘤治疗中的意义。

The therapeutic significance of the novel photodynamic material TPE-IQ-2O in tumors.

机构信息

Department of Thoracic Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Department of Colorectal Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

出版信息

Aging (Albany NY). 2020 Dec 19;13(1):1383-1409. doi: 10.18632/aging.202355.

DOI:10.18632/aging.202355
PMID:33472175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7835032/
Abstract

Combination therapies based on photodynamic therapy (PDT) have received much attention in various cancers due to their strong therapeutic effects. Here, we aimed to explore the safety and effectiveness of a new mitochondria-targeting photodynamic material, TPE-IQ-2O, in combination therapies (combined with surgery or immunotherapy). The safety and effectiveness of TPE-IQ-2O PDT were verified with cytotoxicity evaluation and a zebrafish xenograft model , respectively. The effectiveness of TPE-IQ-2O PDT combined with surgery or immune checkpoint inhibitors (ICIs) was verified in tumor-bearing mice. Small animal imaging, immunohistochemistry, and flow cytometry were used to determine the underlying mechanism. TPE-IQ-2O PDT can not only reduce tumor recurrence in surgical treatment but also effectively improve the response to ICIs in immunotherapy without obvious toxicity. It was also found to ameliorate the immunosuppressive tumor microenvironment and promote the antitumor immunity induced by ICIs by increasing CD8 tumor-infiltrating lymphocyte accumulation. Thus, TPE-IQ-2O PDT is a safe and effective antitumor therapy that can be combined with surgery or immunotherapy.

摘要

基于光动力疗法（PDT）的联合疗法因其强大的治疗效果而在各种癌症中受到广泛关注。在这里，我们旨在探索一种新型线粒体靶向光动力材料 TPE-IQ-2O 在联合疗法（联合手术或免疫疗法）中的安全性和有效性。通过细胞毒性评估和斑马鱼异种移植模型分别验证了 TPE-IQ-2O PDT 的安全性和有效性。在荷瘤小鼠中验证了 TPE-IQ-2O PDT 联合手术或免疫检查点抑制剂（ICIs）的有效性。小动物成像、免疫组织化学和流式细胞术用于确定潜在机制。TPE-IQ-2O PDT 不仅可以减少手术治疗中的肿瘤复发，而且可以有效提高免疫治疗中对 ICIs 的反应，而没有明显的毒性。还发现它可以通过增加 CD8 肿瘤浸润淋巴细胞的积累来改善免疫抑制性肿瘤微环境并促进 ICIs 诱导的抗肿瘤免疫。因此，TPE-IQ-2O PDT 是一种安全有效的抗肿瘤疗法，可以与手术或免疫疗法联合使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/49b61c8ba23a/aging-13-202355-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/5d9bf2f50493/aging-13-202355-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/9e32c92f2f00/aging-13-202355-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/b4e7fc4236ef/aging-13-202355-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/1f5a5470edc7/aging-13-202355-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/57d364f8e3e1/aging-13-202355-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/59a0484c8659/aging-13-202355-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/49b61c8ba23a/aging-13-202355-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/5d9bf2f50493/aging-13-202355-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/89454b372916/aging-13-202355-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/9e32c92f2f00/aging-13-202355-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6577/7835032/b4e7fc4236ef/aging-13-202355-g004.jpg
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本文引用的文献

1
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Int J Nanomedicine. 2020 Mar 19;15:1903-1914. doi: 10.2147/IJN.S239751. eCollection 2020.
2
Multifunctional phototheranostic nanomedicine for cancer imaging and treatment.用于癌症成像与治疗的多功能光诊疗纳米药物
Mater Today Bio. 2019 Nov 6;5:100035. doi: 10.1016/j.mtbio.2019.100035. eCollection 2020 Jan.
3
Three-Pronged Attack by Homologous Far-red/NIR AIEgens to Achieve 1+1+1>3 Synergistic Enhanced Photodynamic Therapy.
脂肪来源的间充质干细胞联合富血小板血浆是治疗骨关节炎的更佳选择。
J Orthop Surg Res. 2025 Jan 2;20(1):2. doi: 10.1186/s13018-024-05396-2.
4
The Latest Look at PDT and Immune Checkpoints.光动力疗法（PDT）与免疫检查点的最新研究进展
Curr Issues Mol Biol. 2024 Jul 8;46(7):7239-7257. doi: 10.3390/cimb46070430.
5
Ginsenoside Rb2 Inhibits the Pyroptosis in Myocardial Ischemia Progression Through Regulating the SIRT1 Mediated Deacetylation of ASC.人参皂苷Rb2通过调节SIRT1介导的ASC去乙酰化抑制心肌缺血进展中的细胞焦亡
Biochem Genet. 2024 Jun 3. doi: 10.1007/s10528-024-10846-x.
6
Roles of reactive oxygen species in inflammation and cancer.活性氧在炎症和癌症中的作用。
MedComm (2020). 2024 Apr 4;5(4):e519. doi: 10.1002/mco2.519. eCollection 2024 Apr.
7
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Cancers (Basel). 2023 Sep 26;15(19):4721. doi: 10.3390/cancers15194721.
8
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9
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Mol Ther Oncolytics. 2023 Jan 2;28:118-131. doi: 10.1016/j.omto.2022.12.009. eCollection 2023 Mar 16.
10
Oxidative Stress in Cancer Immunotherapy: Molecular Mechanisms and Potential Applications.癌症免疫治疗中的氧化应激：分子机制与潜在应用
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Angew Chem Int Ed Engl. 2020 Jun 8;59(24):9610-9616. doi: 10.1002/anie.202000740. Epub 2020 Mar 24.
4
The superior efficacy of anti-PD-1/PD-L1 immunotherapy in KRAS-mutant non-small cell lung cancer that correlates with an inflammatory phenotype and increased immunogenicity.抗 PD-1/PD-L1 免疫疗法在 KRAS 突变型非小细胞肺癌中的优越疗效与炎症表型和增加的免疫原性相关。
Cancer Lett. 2020 Feb 1;470:95-105. doi: 10.1016/j.canlet.2019.10.027. Epub 2019 Oct 20.
5
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Nat Immunol. 2019 Nov;20(11):1425-1434. doi: 10.1038/s41590-019-0512-0. Epub 2019 Oct 14.
6
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7
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8
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9
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10
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Nat Commun. 2019 Jul 26;10(1):3349. doi: 10.1038/s41467-019-11269-8.