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通过给猪接种猪繁殖与呼吸综合征病毒和猪肺炎支原体，随后接种2型猪圆环病毒，对猪呼吸道疾病综合征进行实验性再现。

Experimental reproduction of porcine respiratory disease complex in pigs inoculated porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae and followed by inoculation with porcine circovirus type 2.

作者信息

Lee Joo Young, Park Kee Hwan, Oh Taehwan, Yang Siyeon, Suh Jeongmin, Ham Hee Jin, Chae Chanhee

机构信息

Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, 08826, Seoul, Republic of Korea.

College of Liberal Arts, Anyang University, Samdeok-ro 37, Beob-gil 22, Manan-gu, Anyang-si, Gyeonggi-Do, 14028, Republic of Korea.

出版信息

J Vet Med Sci. 2021 Mar 11;83(3):427-430. doi: 10.1292/jvms.20-0577. Epub 2021 Jan 19.

DOI:10.1292/jvms.20-0577
PMID:33473060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8025419/
Abstract

The aim of this study was to reproduce severe pneumonic lesions, similar to those during naturally-occurring porcine respiratory disease complex, in pigs dually inoculated with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae at 6 weeks of age, followed by inoculation with porcine circovirus type 2 at two weeks after. Time and sequence of infection with three pathogens mirror Asian field conditions. Microscopically, interstitial pneumonia and peribronchiolar lymphoid hyperplasia are considered the most characteristic lung lesions in infected pigs. The results of the present study demonstrate that inoculation of pigs with these three pathogens can lead to severe interstitial pneumonia with peribronchial or peribronchiolar lymphoid hyperplasia and fibrosis.

摘要

本研究的目的是在6周龄时同时接种猪繁殖与呼吸综合征病毒和猪肺炎支原体的猪中再现严重的肺部病变，类似于自然发生的猪呼吸道疾病综合征期间的病变，随后在两周后接种2型猪圆环病毒。三种病原体的感染时间和顺序反映了亚洲的田间情况。在显微镜下，间质性肺炎和支气管周围淋巴组织增生被认为是感染猪最具特征性的肺部病变。本研究结果表明，用这三种病原体接种猪可导致严重的间质性肺炎，并伴有支气管周围或支气管周围淋巴组织增生和纤维化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/8fc5c5a9f48d/jvms-83-427-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/56aef1683315/jvms-83-427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/2429ec44a91c/jvms-83-427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/8fc5c5a9f48d/jvms-83-427-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/56aef1683315/jvms-83-427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/2429ec44a91c/jvms-83-427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0149/8025419/8fc5c5a9f48d/jvms-83-427-g003.jpg

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本文引用的文献

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Vet J. 2016 Jun;212:1-6. doi: 10.1016/j.tvjl.2015.10.030. Epub 2015 Oct 23.
2
Comparison of the pathogenesis of single or dual infections with type 1 and type 2 porcine reproductive and respiratory syndrome virus.1型和2型猪繁殖与呼吸综合征病毒单一感染与双重感染的发病机制比较
J Comp Pathol. 2015 May;152(4):317-24. doi: 10.1016/j.jcpa.2015.03.002. Epub 2015 Apr 11.
3
Immune responses of a chimaeric protein vaccine containing Mycoplasma hyopneumoniae antigens and LTB against experimental M. hyopneumoniae infection in pigs.
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Vaccine. 2014 Aug 6;32(36):4689-94. doi: 10.1016/j.vaccine.2014.05.072. Epub 2014 Jun 5.
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Interaction of porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccines on dually infected pigs.猪圆环病毒 2 型与支原体肺炎疫苗在双重感染猪中的相互作用。
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