Ramahi A J, Lewkow L M, Dombrowski M P, Bottoms S F
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, Michigan.
Obstet Gynecol. 1988 Mar;71(3 Pt 2):493-5.
The incidence of E hemoglobinopathies has been increasing in the United States. This is the first known case report of hemoglobin S/E in pregnancy. Management was based on the similarities of the S/E and S/beta-thalassemia hemoglobinopathies, and included partial exchange transfusion. Complications included fetal distress, congenital hydrocephalus, and cleft lip and palate. It appears that S/E and E/beta-thalassemia hemoglobinopathies may entail increased perinatal risks, but that favorable pregnancy outcomes may be anticipated with homozygous hemoglobin E or hemoglobin E trait.
在美国，E型血红蛋白病的发病率一直在上升。这是已知的首例妊娠期间血红蛋白S/E病例报告。治疗方案基于S/E与S/β地中海贫血血红蛋白病的相似性，包括部分换血疗法。并发症包括胎儿窘迫、先天性脑积水以及唇腭裂。看来S/E和E/β地中海贫血血红蛋白病可能会增加围产期风险，但纯合子血红蛋白E或血红蛋白E性状的妊娠结局可能较好。
