Jennings J C
Am Fam Physician. 1977 Jan;15(1):104-10.
Sickle cell trait is associated with an increased incidence of asymptomatic bacteriuria, low birth weight infants and premature rupture of membranes. Hemoglobin SS and hemoglobin SC in pregnancy result in significantly increased maternal morbidity and mortality and reproductive wastage. Heterozygous thalassemias in pregnancy carry increased risks but to a lesser degree than hemoglobins SS and SC. Partial exchange transfusion can provide effective prophylaxis for many of the maternal and fetal problems of sickle cell disease.
镰状细胞性状与无症状菌尿、低体重儿和胎膜早破的发生率增加有关。妊娠期血红蛋白SS和血红蛋白SC会导致孕产妇发病率、死亡率及生殖损耗显著增加。妊娠期杂合子地中海贫血也有较高风险，但程度低于血红蛋白SS和SC。部分换血疗法可为镰状细胞病的许多母婴问题提供有效预防。
