Department of Critical Care Medicine, Huantai County People's Hospital, Zibo, China.
Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China.
Int J Clin Pract. 2021 Aug;75(8):e14031. doi: 10.1111/ijcp.14031. Epub 2021 Feb 17.
The ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Excluded typical manifestation of pneumonia and acute respiratory symptoms, COVID-19 patients also have abnormal D-dimer concentration in the serum, but the results are controversial.
A meta-analysis first aims to explored the connection between D-dimer concentration and COVID-19 patients.
Our results found a significant relationship between D-dimer and COVID-19, with a pooled OR of 1.90 (95% CI: 1.32-2.48; P < .001). The pooled data were calculated with the REM as a high heterogeneity within the studies. The sensitivity analysis results showed that the WMD ranged from 1.69 (95% CI: 1.15 to 2.23) to 2.06 (95% CI: 1.51 to 2.62) and there was no publication bias.
Our meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. Meanwhile, the severe COVID-19 patients tend to have a higher concentration of D-dimer when compared with non-severe patients.
We used MASH word and searched the online database and followed the inclusion and exclusion standard. The detailed information can be found in the text.
Our meta-analysis showed that the severity of patients with COVID-19 significance related to D-dimer concentrations. This may be helpful for the clinic COVID-19 patients.
由新型冠状病毒综合征冠状病毒 2（SARS-CoV-2）引起的持续的 COVID-19 大流行是一种新兴的、迅速演变的情况。除了肺炎和急性呼吸道症状的典型表现外，COVID-19 患者的血清中也存在异常的 D-二聚体浓度，但结果存在争议。
一项荟萃分析旨在首先探讨 D-二聚体浓度与 COVID-19 患者之间的关系。
我们的结果发现 D-二聚体与 COVID-19 之间存在显著关系，合并 OR 为 1.90（95%CI：1.32-2.48；P<0.001）。合并数据显示研究内存在高度异质性。敏感性分析结果表明，WMD 范围为 1.69（95%CI：1.15-2.23）至 2.06（95%CI：1.51-2.62），不存在发表偏倚。
我们的荟萃分析表明，COVID-19 患者的严重程度与 D-二聚体浓度有显著关系。同时，与非重症患者相比，重症 COVID-19 患者的 D-二聚体浓度往往更高。
我们使用 MASH 词并搜索了在线数据库，并遵循了纳入和排除标准。详细信息可在文本中找到。
我们的荟萃分析表明，COVID-19 患者的严重程度与 D-二聚体浓度有显著关系。这可能对临床 COVID-19 患者有帮助。
