Cancer J. 2021;27(1):17-24. doi: 10.1097/PPO.0000000000000502.
Obesity is an increasingly prevalent state of energy imbalance that contributes to breast cancer risk and outcomes. The effects of obesity differ by breast cancer subtype and menopause. While most studies have focused on postmenopausal hormone receptor-positive disease, less is known about the relationship between obesity and triple-negative breast cancer (TNBC). Here we will review the observations linking obesity to TNBC, the socioeconomic disparities that contribute to obesity-related TNBC, and putative biologic mechanisms. Finally, we will consider the impact of obesity on surgical and medical treatment of TNBC and novel strategies to improve energy balance after cancer diagnosis.
肥胖是一种日益普遍的能量失衡状态，会增加罹患乳腺癌的风险并影响其预后。肥胖对乳腺癌亚型和绝经状态的影响不同。虽然大多数研究都集中在绝经后激素受体阳性疾病上，但对于肥胖与三阴性乳腺癌（TNBC）之间的关系知之甚少。在这里，我们将回顾肥胖与 TNBC 相关的观察结果、导致肥胖相关 TNBC 的社会经济差异以及推测的生物学机制。最后，我们将考虑肥胖对 TNBC 手术和药物治疗的影响以及改善癌症诊断后能量平衡的新策略。
