Li Meng-Hui, Si Xiao-Ju, Zhang He, Yang Dandan, Niu Jun-Long, Song Mao-Ping
Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China.
Org Lett. 2021 Feb 5;23(3):914-919. doi: 10.1021/acs.orglett.0c04122. Epub 2021 Jan 21.
Herein, we disclose an efficient cobalt-catalyzed three-component coupling of benzamides, diazo compounds, and -butyl hydroperoxide, which provides an efficient approach to construct C(sp)-C(sp) and C-O bonds in one-pot accompanied with C-H activation. This protocol features low catalyst loading (4 mol %), the avoidance of additives, and excellent functional group compatibility, providing three-component coupling adducts with high yields under mild conditions (up to 88%). Mechanism studies show that the reaction may involve a radical process.
在此，我们报道了一种高效的钴催化苯甲酰胺、重氮化合物和叔丁基过氧化氢的三组分偶联反应，该反应提供了一种在一锅反应中伴随C-H活化构建C(sp)-C(sp)和C-O键的有效方法。该方法具有催化剂负载量低（4 mol%）、无需添加剂以及优异的官能团兼容性等特点，能在温和条件下以高产率（高达88%）得到三组分偶联加合物。机理研究表明该反应可能涉及自由基过程。
