基于溶酶体靶向和近红外吸收的 Ru(ii)-BODIPY 轭合物的理性设计用于光动力疗法。
Rational design of a lysosome-targeting and near-infrared absorbing Ru(ii)-BODIPY conjugate for photodynamic therapy.
机构信息
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
出版信息
Chem Commun (Camb). 2021 Feb 18;57(14):1790-1793. doi: 10.1039/d0cc06926d. Epub 2021 Jan 21.
PMID:33475648
Abstract
A Ru(ii)-BODIPY conjugate has been rationally designed and exhibits an intense absorption in the NIR region to boost lysosome-targeted PDT in vitro and in vivo. The advantages of Ru(ii) and BODIPY were successfully instilled into the conjugate to yield highly effective PDT efficacy against malignant melanoma A375 cells (PI = 3448) and A375 mice xenografts.
摘要
一种 Ru(ii)-BODIPY 缀合物被合理设计，在近红外区域表现出强烈的吸收，以在体外和体内增强溶酶体靶向 PDT。成功地将 Ru(ii)和 BODIPY 的优势注入缀合物中，对恶性黑色素瘤 A375 细胞（PI = 3448）和 A375 小鼠异种移植物产生了高效的 PDT 疗效。
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