Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Departamento de Química-Física, Universidad del País Vasco-EHU, Apartado 644, 48080 Bilbao, Spain.
Org Lett. 2022 May 27;24(20):3636-3641. doi: 10.1021/acs.orglett.2c01169. Epub 2022 May 16.
We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprecedented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.
我们已经建立了一种简单的合成方案，通过选择性地开发基于关键二聚体前体的甲基氧化与亲电甲酰化的所有正交 BODIPY 三聚体，从而获得前所未有的几何形状。光物理特性分析和生物学测定揭示了三聚体中最适合的 BODIPY-BODIPY 几何排列，迫使它们作为发展新型、先进的无重原子光敏剂的分子平台，用于光动力治疗和光诊断。
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