Luo Tao, Fan Sisi, Liu Yan, Song Jie
Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Nanoscale. 2021 Feb 4;13(4):2100-2112. doi: 10.1039/d0nr07865d.
SemiSynBio is an emerging topic toward the construction of platforms for next-generation information processing. Recent research has indicated its promising prospect toward information processing including algorithm design and pattern manipulation with the DNA TMSD reaction, which is one of the cores of the SemiSynBio technology route. The DNA TMSD reaction is the process in which an invader strand displaces the incumbent strand from the gate strand through initiation at the exposed toehold domain. Also, the DNA TMSD reaction generally involves three processes: toehold association, branch migration and strand disassociation. Herein, we review the recent progress on information processing with the DNA TMSD reaction. We highlight the diverse developments on information processing with the logic circuit, analog circuit, combinational circuit and information relay with the DNA origami structure. Additionally, we explore the current challenges and various trends toward the design and application of the DNA TMSD reaction in future information processing.
半合成生物学是构建下一代信息处理平台的一个新兴课题。最近的研究表明，它在信息处理方面具有广阔的前景，包括利用DNA三链体介导的链置换反应（TMSD反应）进行算法设计和模式操纵，这是半合成生物学技术路线的核心之一。DNA TMSD反应是入侵链通过在暴露的分支结构域起始，从门链上置换在位链的过程。此外，DNA TMSD反应通常涉及三个过程：分支结构域结合、分支迁移和链解离。在此，我们综述了利用DNA TMSD反应进行信息处理的最新进展。我们重点介绍了利用逻辑电路、模拟电路、组合电路以及基于DNA折纸结构的信息中继进行信息处理的各种进展。此外，我们探讨了DNA TMSD反应在未来信息处理中的设计和应用面临的当前挑战及各种趋势。
