Zhou Hong-Mei, Qiu Qiu, Yan Meng-Huan, Peng Li-Juan, Fang Jing-Jing, Zhou Bing-Jie, Yang Sha-Sha, Zhang Gang-Cheng
Congenital Heart Disease Center, Wuhan Asia Heart Hospital, Wuhan 430000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2021 Jan;23(1):78-83. doi: 10.7499/j.issn.1008-8830.2007203.
To study the effect of calorie-enriched formula on postoperative catch-up growth in infants with cyanotic congenital heart disease (CHD).
A total of 100 infants with cyanotic CHD who underwent surgical operation from January to December, 2017, were randomly divided into a high-calorie group (receiving calorie-enriched formula after surgery) and a conventional group (receiving standard formula after surgery), with 50 infants in each group. All infants were followed up for 6 months. The observation indices included body height, body weight, prealbumin, and N-terminal pro-brain natriuretic peptide before surgery, at the time of ventilator weaning and extubation after surgery, and at 1, 3, and 6 months after surgery. Height-for-age Z-score (HAZ), weight-for-age Z-score (WAZ), and weight-for-height Z-score (WHZ) were also assessed. Adverse reactions were recorded for both groups.
There were 25 cases (50%) and 21 cases (42%) of malnutrition in the high-calorie group and the conventional group respectively before surgery ( > 0.05). The nutritional status of the two groups improved 6 months after surgery ( < 0.05). At 6 months after surgery, compared with the conventional group, the high-calorie group had a lower proportion of infants with malnutrition (18% vs 36%, < 0.05) and also a lower proportation of infants with a WAZ score of < -2 ( < 0.05). The infants with malnutrion in the high-calorie group had higher HAZ, WAZ, and WHZ than those in the conventional group ( < 0.05). No gastrointestinal intolerance was observed in both groups during hospitalization.
Compared with the standard formula, calorie-enriched formula can better help with postoperative catch-up growth in infants with cyanotic CHD.
研究高热量配方奶对青紫型先天性心脏病（CHD）患儿术后追赶生长的影响。
选取2017年1月至12月接受手术治疗的100例青紫型CHD患儿，随机分为高热量组（术后接受高热量配方奶）和常规组（术后接受标准配方奶），每组50例。所有患儿均随访6个月。观察指标包括术前、术后脱机拔管时、术后1、3和6个月时的身高、体重、前白蛋白和N末端脑钠肽前体。还评估了年龄别身高Z评分（HAZ）、年龄别体重Z评分（WAZ）和身高别体重Z评分（WHZ）。记录两组的不良反应。
术前高热量组和常规组分别有25例（50%）和21例（42%）营养不良（>0.05）。两组术后6个月营养状况均有改善（<0.05）。术后6个月，与常规组相比，高热量组营养不良患儿比例较低（18%对36%，<0.05），WAZ评分<-2的患儿比例也较低（<0.05）。高热量组营养不良患儿的HAZ、WAZ和WHZ高于常规组（<0.05）。住院期间两组均未观察到胃肠道不耐受情况。
与标准配方奶相比，高热量配方奶能更好地帮助青紫型CHD患儿术后追赶生长。
