p53 靶向长链非编码 RNA ST7-AS1 通过与 PTBP1 相互作用抑制胶质瘤中的 Wnt/β-catenin 信号通路，发挥抑癌作用。
p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma.
机构信息
Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.
Department of Hematology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China.
出版信息
Cancer Lett. 2021 Apr 10;503:54-68. doi: 10.1016/j.canlet.2020.12.039. Epub 2021 Jan 19.
Glioma is the most prevalent intracranial tumour, with considerable morbidity. Long non-coding RNAs are important in the biological processes of various cancers. However, little is known about ST7 antisense RNA 1 (ST7-AS1) and its role in glioma progression. ST7-AS1 expression was reduced in glioma tissues and cells in comparison to normal brain tissues. p53 transcriptionally targeted the ST7-AS1 promoter in U251 glioma cells. The targeting significantly inhibited cell migration, invasion, and proliferation, and promoted apoptosis. ST7-AS1 directly bound to and downregulated polypyrimidine tract-binding protein 1 (PTBP1) at the post-transcriptional level. ST7-AS1 overexpression inhibited glioma progression by suppressing Wnt/β-catenin signalling by downregulating PTBP1 expression. Additionally, p53 expression negatively correlated with PTBP1 expression. Glioma progression is regulated by a positive feedback loop involving the p53/ST7-AS1/PTBP1 axis, which might be a promising therapeutic target for glioma treatment.
神经胶质瘤是最常见的颅内肿瘤，具有相当高的发病率。长链非编码 RNA 在各种癌症的生物学过程中起着重要作用。然而，关于 ST7 反义 RNA 1（ST7-AS1）及其在神经胶质瘤进展中的作用知之甚少。与正常脑组织相比，ST7-AS1 在神经胶质瘤组织和细胞中的表达降低。p53 在 U251 神经胶质瘤细胞中转录靶向 ST7-AS1 启动子。这种靶向作用显著抑制细胞迁移、侵袭和增殖，并促进细胞凋亡。ST7-AS1 直接结合并下调多嘧啶 tract-binding protein 1（PTBP1）在转录后水平。ST7-AS1 通过下调 PTBP1 表达抑制 Wnt/β-catenin 信号通路抑制神经胶质瘤进展。此外，p53 表达与 PTBP1 表达呈负相关。神经胶质瘤的进展受 p53/ST7-AS1/PTBP1 轴的正反馈环调控，这可能是神经胶质瘤治疗的有希望的治疗靶点。
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