Cui Shiwen, Peng Qiu, Ma Qianfeng, Xu Xuemeng, Zhang Wenlong, Jiang Xianjie, Tan Shiming, Yang Wenjuan, Han Yaqian, Oyang Linda, Li Shizhen, Lin Jinguan, Wang Jiewen, Xia Longzheng, Peng Mingjing, Wu Nayiyuan, Tang Yanyan, Liao Qianjin, Zhou Yujuan
Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, China.
Hunan Engineering Research Center of Tumor organoid Technology and application, Public Service Platform of Tumor organoids Technology, 283 Tongzipo Road, Changsha, 410013, Hunan, China.
Int J Biol Sci. 2025 Apr 21;21(7):2991-3010. doi: 10.7150/ijbs.109593. eCollection 2025.
RNA-binding proteins, integral in regulating RNA metabolism and gene expression, collaborate closely with non-coding RNAs, which are pivotal in post-transcriptional gene regulation. Both elements are essential for the progression of tumors. While recent research has increasingly illuminated their individual mechanisms, the intricate network interplay between them still requires further exploration. This article has provided a comprehensive review of the roles played by RNA-binding proteins and their associated non-coding RNAs in tumor biology. It delves into the intricate functions of various RNA-binding proteins in tumors, including their involvement in alternative splicing, m6A modification, alternative polyadenylation, and phase separation. Furthermore, it highlights the diverse and significant roles of different non-coding RNAs, such as microRNAs, long non-coding RNAs, and circRNAs, in tumor progression. The interaction between RNA-binding proteins and regulated non-coding RNAs is also explored, providing insights into their collective impact on metabolic reprogramming, immunity, drug resistance, metastasis, and ferroptosis. This in-depth exploration not only deepens our understanding of the mechanisms underlying tumorigenesis but also lays a foundation for developing innovative therapeutic strategies.
RNA结合蛋白在调节RNA代谢和基因表达中不可或缺，它们与非编码RNA密切协作，而非编码RNA在转录后基因调控中起着关键作用。这两种成分对肿瘤进展都至关重要。尽管最近的研究越来越多地阐明了它们各自的机制，但它们之间复杂的网络相互作用仍需进一步探索。本文全面综述了RNA结合蛋白及其相关非编码RNA在肿瘤生物学中的作用。它深入探讨了各种RNA结合蛋白在肿瘤中的复杂功能，包括它们在可变剪接、m6A修饰、可变多聚腺苷酸化和相分离中的作用。此外，它突出了不同非编码RNA，如微小RNA、长链非编码RNA和环状RNA在肿瘤进展中的多样且重要的作用。还探讨了RNA结合蛋白与受调控的非编码RNA之间的相互作用，为它们对代谢重编程、免疫、耐药性、转移和铁死亡的共同影响提供了见解。这种深入探索不仅加深了我们对肿瘤发生机制的理解，也为开发创新治疗策略奠定了基础。
