Gonzalez Elizabeth, Flatt Terrie G, Farooqi Midhat, Johnson Lisa, Ahmed Atif A
Pediatric Hematology Oncology, Children Mercy Hospital, Kansas City, Missouri, USA.
Departments of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, Missouri, USA.
Curr Mol Med. 2024;24(12):1450-1460. doi: 10.2174/0115665240251370231017053236.
Polypyrimidine tract binding protein is a 57-Kda protein located in the perinucleolar compartment where it binds RNA and regulates several biological functions through the regulation of RNA splicing. Numerous research articles have been published that address the cellular network and functions of PTB and its isoforms in various disease states.
Through an extensive PubMed search, we attempt to summarize the relevant research into this biomolecule.
Besides its roles in embryonic development, neuronal cell growth, RNA metabolism, apoptosis, and hematopoiesis, PTB can affect cancer growth via several metabolic, proliferative, and structural mechanisms. PTB overexpression has been documented in several cancers where it plays a role as a novel prognostic factor.
The diverse carcinogenic effect opens an argument into its potential role in inhibitory targeted therapy.
多嘧啶序列结合蛋白是一种57千道尔顿的蛋白质，位于核仁周区，在那里它与RNA结合，并通过调节RNA剪接来调控多种生物学功能。已经发表了许多研究文章，探讨了PTB及其异构体在各种疾病状态下的细胞网络和功能。
通过广泛的PubMed搜索，我们试图总结对这种生物分子的相关研究。
除了在胚胎发育、神经元细胞生长、RNA代谢、细胞凋亡和造血作用中的作用外，PTB还可通过多种代谢、增殖和结构机制影响癌症生长。在几种癌症中已记录到PTB过表达，它在其中作为一种新的预后因素发挥作用。
这种多样的致癌作用引发了关于其在抑制性靶向治疗中潜在作用的讨论。
