全血、固定比例或目标导向性血液成分疗法用于严重出血创伤患者的初始复苏：一项叙述性综述
Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review.
作者信息
Walsh Mark, Moore Ernest E, Moore Hunter B, Thomas Scott, Kwaan Hau C, Speybroeck Jacob, Marsee Mathew, Bunch Connor M, Stillson John, Thomas Anthony V, Grisoli Annie, Aversa John, Fulkerson Daniel, Vande Lune Stefani, Sjeklocha Lucas, Tran Quincy K
机构信息
Notre Dame Campus, Indiana University School of Medicine, South Bend, IN 46617, USA.
Departments of Emergency & Internal Medicine, Saint Joseph Regional Medical Center, Mishawaka, IN 46545, USA.
出版信息
J Clin Med. 2021 Jan 17;10(2):320. doi: 10.3390/jcm10020320.
Abstract
This narrative review explores the pathophysiology, geographic variation, and historical developments underlying the selection of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. We also detail a physiologically driven and goal-directed alternative to fixed ratio and whole blood, whereby viscoelastic testing guides the administration of blood components and factor concentrates to the severely bleeding trauma patient. The major studies of each resuscitation method are highlighted, and upcoming comparative trials are detailed.
摘要
本叙述性综述探讨了在出血性创伤患者中选择固定比例复苏与全血复苏的病理生理学、地域差异及历史发展情况。我们还详细介绍了一种基于生理驱动且目标导向的固定比例和全血复苏替代方案，即通过粘弹性检测指导向严重出血创伤患者输注血液成分和凝血因子浓缩剂。文中突出了每种复苏方法的主要研究，并详述了即将开展的对比试验。
相似文献
1
Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review.全血、固定比例或目标导向性血液成分疗法用于严重出血创伤患者的初始复苏：一项叙述性综述
J Clin Med. 2021 Jan 17;10(2):320. doi: 10.3390/jcm10020320.
2
Advances in trauma care to save lives from traumatic injury: A narrative review.创伤护理的进展：挽救创伤性损伤患者的生命：叙事性综述。
J Trauma Acute Care Surg. 2023 Aug 1;95(2):285-292. doi: 10.1097/TA.0000000000003960. Epub 2023 Mar 21.
3
Exsanguination in trauma: A review of diagnostics and treatment options.创伤性失血：诊断与治疗选择综述
Injury. 2009 Jan;40(1):11-20. doi: 10.1016/j.injury.2008.10.007. Epub 2009 Jan 8.
4
Whole Blood for Civilian Urban Trauma Resuscitation: Historical, Present, and Future Considerations.全血用于民用城市创伤复苏：历史、现状和未来的考虑。
Semin Thromb Hemost. 2020 Mar;46(2):221-234. doi: 10.1055/s-0040-1702174. Epub 2020 Mar 11.
5
Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Center.在前沿作战和严峻民用环境中，基于黏弹性成像指导的出血性复苏：远离创伤中心的目标导向性全血和血液成分治疗
J Clin Med. 2022 Jan 12;11(2):356. doi: 10.3390/jcm11020356.
6
Trauma-induced coagulopathy: Mechanisms and clinical management.创伤性凝血病：发病机制与临床管理。
Ann Acad Med Singap. 2022 Jan;51(1):40-48. doi: 10.47102/annals-acadmedsg.2020381.
7
Early haemorrhage control and management of trauma-induced coagulopathy: the importance of goal-directed therapy.早期出血控制和创伤诱导性凝血病的管理：目标导向治疗的重要性。
Curr Opin Crit Care. 2017 Dec;23(6):503-510. doi: 10.1097/MCC.0000000000000466.
8
Plasma transfusion for patients with severe hemorrhage: what is the evidence?血浆输注治疗严重出血患者：有何证据？
Transfusion. 2012 May;52 Suppl 1:30S-7S. doi: 10.1111/j.1537-2995.2012.03621.x.
9
Fixed ratio versus goal-directed therapy in trauma.创伤治疗中固定比例法与目标导向疗法的对比
Curr Opin Anaesthesiol. 2016 Apr;29(2):234-44. doi: 10.1097/ACO.0000000000000278.
10
Effectiveness and safety of whole blood compared to balanced blood components in resuscitation of hemorrhaging trauma patients - A systematic review.全血与平衡血液成分在出血性创伤患者复苏中的效果和安全性比较 - 系统评价。
Injury. 2021 Feb;52(2):182-188. doi: 10.1016/j.injury.2020.10.095. Epub 2020 Oct 31.
引用本文的文献
1
The Effect of Heterogeneous Definitions of Massive Transfusion on Using Blood Component Thresholds to Predict Futility in Severely Bleeding Trauma Patients.大量输血的异质性定义对使用血液成分阈值预测严重出血创伤患者治疗无效性的影响。
J Clin Med. 2025 Aug 1;14(15):5426. doi: 10.3390/jcm14155426.
2
Transfusion in trauma: empiric or guided therapy?创伤输血：经验性治疗还是指导性治疗？
Res Pract Thromb Haemost. 2024 Dec 24;9(1):102663. doi: 10.1016/j.rpth.2024.102663. eCollection 2025 Jan.
3
Markers of Futile Resuscitation in Traumatic Hemorrhage: A Review of the Evidence and a Proposal for Futility Time-Outs during Massive Transfusion.创伤性出血中复苏无效的标志物：证据综述及大量输血期间无效复苏暂停提议
J Clin Med. 2024 Aug 9;13(16):4684. doi: 10.3390/jcm13164684.
4
Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress.国际血栓与止血学会（ISTH）2024年大会的最新胶囊图解。
Res Pract Thromb Haemost. 2024 May 3;8(4):102432. doi: 10.1016/j.rpth.2024.102432. eCollection 2024 May.
5
Anesthetic managements, morbidities and mortalities in retroperitoneal sarcoma patients experiencing perioperative massive blood transfusion.腹膜后肉瘤患者围手术期大量输血时的麻醉管理、并发症及死亡率
Front Oncol. 2024 Mar 5;14:1347248. doi: 10.3389/fonc.2024.1347248. eCollection 2024.
6
Resonant Acoustic Rheometry to Measure Coagulation Kinetics in Hemophilia A and Healthy Plasma: A Novel Viscoelastic Method.谐振声学法测量血友病 A 和健康血浆中的凝血动力学：一种新的粘弹性方法。
Semin Thromb Hemost. 2023 Mar;49(2):201-208. doi: 10.1055/s-0042-1757896. Epub 2022 Nov 1.
7
Use of Thromboelastography and Rotational Thromboelastometry in Otolaryngology: A Narrative Review.血栓弹力图和旋转血栓弹力测定法在耳鼻喉科的应用：一篇叙述性综述
J Clin Med. 2022 Feb 20;11(4):1119. doi: 10.3390/jcm11041119.
8
Emergency Blood Transfusion for Trauma and Perioperative Resuscitation: Standard of Care.创伤及围手术期复苏的紧急输血：护理标准
Transfus Med Hemother. 2021 Oct 29;48(6):366-376. doi: 10.1159/000519696. eCollection 2021 Dec.
9
Hemorrhagic Resuscitation Guided by Viscoelastography in Far-Forward Combat and Austere Civilian Environments: Goal-Directed Whole-Blood and Blood-Component Therapy Far from the Trauma Center.在前沿作战和严峻民用环境中，基于黏弹性成像指导的出血性复苏：远离创伤中心的目标导向性全血和血液成分治疗
J Clin Med. 2022 Jan 12;11(2):356. doi: 10.3390/jcm11020356.
10
Viscoelastic Testing and Coagulopathy of Traumatic Brain Injury.创伤性脑损伤的粘弹性测试与凝血病
J Clin Med. 2021 Oct 28;10(21):5039. doi: 10.3390/jcm10215039.
本文引用的文献
1
Efficacy of prehospital administration of fibrinogen concentrate in trauma patients bleeding or presumed to bleed (FIinTIC): A multicentre, double-blind, placebo-controlled, randomised pilot study.创伤患者出血或疑似出血时院前给予纤维蛋白原浓缩物的疗效（FIinTIC）：一项多中心、双盲、安慰剂对照、随机先导研究。
Eur J Anaesthesiol. 2021 Apr 1;38(4):348-357. doi: 10.1097/EJA.0000000000001366.
2
Modern methods for monitoring hemorrhagic resuscitation in the United States: Why the delay?美国监测出血性复苏的现代方法：为何延迟？
J Trauma Acute Care Surg. 2020 Dec;89(6):1018-1022. doi: 10.1097/TA.0000000000002977.
3
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial.黏弹性止血检测增强方案治疗创伤大出血（ITACTIC）：一项随机对照试验。
Intensive Care Med. 2021 Jan;47(1):49-59. doi: 10.1007/s00134-020-06266-1. Epub 2020 Oct 13.
4
Thromboelastography and rotational thromboelastometry in bleeding patients with coagulopathy: Practice management guideline from the Eastern Association for the Surgery of Trauma.凝血功能障碍出血患者的血栓弹力描记术和旋转血栓弹力描记术：东部创伤外科学会的实践管理指南。
J Trauma Acute Care Surg. 2020 Dec;89(6):999-1017. doi: 10.1097/TA.0000000000002944.
5
Whole Blood is Superior to Component Transfusion for Injured Children: A Propensity Matched Analysis.全血输注优于成分输血治疗创伤患儿：倾向评分匹配分析。
Ann Surg. 2020 Oct;272(4):590-594. doi: 10.1097/SLA.0000000000004378.
6
A comparison between leukocyte reduced low titer whole blood vs non-leukocyte reduced low titer whole blood for massive transfusion activation.白细胞减少的低滴度全血与非白细胞减少的低滴度全血在大量输血激活方面的比较。
Transfusion. 2020 Dec;60(12):2834-2840. doi: 10.1111/trf.16066. Epub 2020 Sep 5.
7
Pre-hospital blood transfusion - an ESA survey of European practice.院前输血 - 欧洲实践的 ESA 调查。
Scand J Trauma Resusc Emerg Med. 2020 Aug 14;28(1):79. doi: 10.1186/s13049-020-00774-1.
8
Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma.全国范围内对民用创伤患者全血止血复苏的分析。
J Trauma Acute Care Surg. 2020 Aug;89(2):329-335. doi: 10.1097/TA.0000000000002753.
9
Site-Of-Care Viscoelastic Assay in Major Trauma Improves Outcomes and Is Cost Neutral Compared with Standard Coagulation Tests.重大创伤中床旁粘弹性检测可改善预后，与标准凝血检测相比成本相当。
Diagnostics (Basel). 2020 Jul 17;10(7):486. doi: 10.3390/diagnostics10070486.
10
Bleeding to death in a big city: An analysis of all trauma deaths from hemorrhage in a metropolitan area during 1 year.大城市中的出血性死亡：对某一都市地区 1 年内所有因出血导致的创伤性死亡的分析。
J Trauma Acute Care Surg. 2020 Oct;89(4):716-722. doi: 10.1097/TA.0000000000002833.
Zotero 插件