Panagides Vassili, Vase Henrik, Shah Sachin P, Basir Mir B, Mancini Julien, Kamran Hayaan, Batra Supria, Laine Marc, Eiskjær Hans, Christensen Steffen, Karami Mina, Paganelli Franck, Henriques Jose P S, Bonello Laurent
Intensive Care Unit, Department of Cardiology, Assistance Publique-Hôpitaux de Marseille, Hôpital Nord, Aix-Marseille University, 13015 Marseille, France.
Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), 13015 Marseille, France.
J Clin Med. 2021 Jan 18;10(2):339. doi: 10.3390/jcm10020339.
Impella CP is a left ventricular pump which may serve as a circulatory support during cardiopulmonary resuscitation (CPR) for cardiac arrest (CA). Nevertheless, the survival rate and factors associated with survival in patients undergoing Impella insertion during CPR for CA are unknown.
We performed a retrospective multicenter international registry of patients undergoing Impella insertion during on-going CPR for in- or out-of-hospital CA. We recorded immediate and 30-day survival with and without neurologic impairment using the cerebral performance category score and evaluated the factors associated with survival.
Thirty-five patients had an Impella CP implanted during CPR for CA. Refractory ventricular arrhythmias were the most frequent initial rhythm (65.7%). In total, 65.7% of patients immediately survived. At 30 days, 45.7% of patients were still alive. The 30-day survival rate without neurological impairment was 37.1%. In univariate analysis, survival was associated with both an age < 75 years and a time from arrest to CPR ≤ 5 min ( = 0.035 and = 0.008, respectively).
In our multicenter registry, Impella CP insertion during ongoing CPR for CA was associated with a 37.1% rate of 30-day survival without neurological impairment. The factors associated with survival were a young age and a time from arrest to CPR ≤ 5 min.
Impella CP是一种左心室泵，可在心脏骤停（CA）的心肺复苏（CPR）期间作为循环支持。然而，在CA的CPR期间接受Impella植入的患者的生存率及与生存相关的因素尚不清楚。
我们对正在进行院内心脏骤停或院外心脏骤停CPR期间接受Impella植入的患者进行了一项回顾性多中心国际注册研究。我们使用脑功能分类评分记录有无神经功能障碍的即时生存率和30天生存率，并评估与生存相关的因素。
35例患者在CA的CPR期间植入了Impella CP。难治性室性心律失常是最常见的初始心律（65.7%）。总共有65.7%的患者即时存活。在30天时，45.7%的患者仍存活。无神经功能障碍的30天生存率为37.1%。在单因素分析中，生存与年龄<75岁以及从心脏骤停到CPR的时间≤5分钟均相关（分别为P = 0.035和P = 0.008）。
在我们的多中心注册研究中，在CA的持续CPR期间植入Impella CP与无神经功能障碍的30天生存率为37.1%相关。与生存相关的因素是年轻和从心脏骤停到CPR的时间≤5分钟。
