小鼠、猴子和人类中mRNA疫苗诱导的免疫反应。
Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans.
作者信息
Cagigi Alberto, Loré Karin
机构信息
Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, 161 64 Solna, Sweden.
出版信息
Vaccines (Basel). 2021 Jan 18;9(1):61. doi: 10.3390/vaccines9010061.
Abstract
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
摘要
在这篇简短的综述中，我们总结了mRNA疫苗接种背后的概念。我们讨论了mRNA疫苗在不同动物模型和人类中产生的先天性和适应性免疫反应。我们列举了一些mRNA疫苗已显示出能诱导强烈反应的病毒感染实例，并更详细地讨论了最近在人类中进行的SARS-CoV-2 mRNA疫苗试验。
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