BNT162b2 疫苗诱导的血清对 SARS-CoV-2 刺突 69/70 缺失、E484K 和 N501Y 变异株的中和作用。
Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
机构信息
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.
Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Nat Med. 2021 Apr;27(4):620-621. doi: 10.1038/s41591-021-01270-4. Epub 2021 Feb 8.
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
我们构建了三种含有新型出现的英国（UK）和南非（SA）变体关键刺突突变的严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）病毒：来自 UK 的 N501Y 和 SA；来自 UK 的 69/70-缺失+N501Y+D614G；以及来自 SA 的 E484K+N501Y+D614G。20 份 BTN162b2 疫苗诱导的人类血清对三种突变病毒的中和几何平均滴度（GMT）比针对亲代病毒的 GMT 低 0.81-1.46 倍，表明这些突变对由两剂 BNT162b2 引起的血清的中和作用影响较小。
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