Laboratory for Oxidative Stress, Division of Molecular Medicine Rudjer Boskovic Institute, 10000 Zagreb, Croatia.
Polyclinic Department of Dermatology and Venereology, University Hospital Dubrava, 10000 Zagreb, Croatia.
Molecules. 2021 Aug 31;26(17):5301. doi: 10.3390/molecules26175301.
Impaired systemic redox homeostasis is implicated in the onset and development of various diseases, including skin diseases. Therefore, continuous search for natural products with antioxidant bioactivities applicable in biomedicine is attractive topic of general interest. Research efforts aiming to validate antioxidant potentials of natural products has led to the development of several assays based on various test principles. Hence, understanding the advantages and limitations of various assays is important for selection of assays useful to study antioxidant and related bioactivities of natural products of biomedical interest. This review paper gives a short overview on some chemical and cellular bioassays used to estimate the antioxidant activity of chosen natural products together with a brief overview on the use of natural products with antioxidant activities as adjuvant medicinal remedies in dermatology.
系统氧化还原平衡失调与多种疾病的发生和发展有关，包括皮肤病。因此，不断寻找具有抗氧化生物活性、可应用于生物医学领域的天然产物是一个备受关注的话题。旨在验证天然产物抗氧化潜力的研究工作已经导致了基于各种测试原理的几种测定方法的发展。因此，了解各种测定方法的优缺点对于选择有用的测定方法来研究具有生物医学意义的天然产物的抗氧化和相关生物活性非常重要。本文综述了一些用于评估所选天然产物抗氧化活性的化学和细胞生物测定方法，并简要概述了具有抗氧化活性的天然产物作为辅助药物在皮肤病学中的应用。
