内分泌干扰化学物质与甲状腺癌：概述
Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview.
作者信息
Alsen Mathilda, Sinclair Catherine, Cooke Peter, Ziadkhanpour Kimia, Genden Eric, van Gerwen Maaike
机构信息
Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Medical Education, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Toxics. 2021 Jan 19;9(1):14. doi: 10.3390/toxics9010014.
Abstract
Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.
摘要
已知内分泌干扰化学物质（EDC）会改变甲状腺功能，并与某些癌症风险增加有关。本研究旨在全面概述关于EDC暴露与甲状腺癌之间关联的现有研究。通过在美国国立医学图书馆和国立卫生研究院的PubMed数据库中进行文献检索，以及查阅所有检索到的文章的参考文献列表和先前发表的相关综述，确定了相关研究。总体而言，当前文献表明，接触某些阻燃剂、多氯联苯（PCB）和邻苯二甲酸酯的同系物以及某些农药可能与甲状腺癌风险增加有关。然而，迫切需要未来的研究来评估不同的EDC及其对人类甲状腺的潜在致癌作用，因为大多数EDC只是零星研究，结果并不一致。
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