Woods Meghan M, Lanphear Bruce P, Braun Joseph M, McCandless Lawrence C
Faculty of Health Sciences, Simon Fraser University, Blusson Hall, Rm 11300, 8888 University Drive, Burnaby, British Columbia, V5A 1S6, Canada.
Child and Family Research Institute, BC Children's and Women's Hospital, 950 West 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada.
Environ Health. 2017 Oct 27;16(1):115. doi: 10.1186/s12940-017-0332-3.
Pregnant women are exposed to a mixture of endocrine disrupting chemicals (EDCs). Gestational EDC exposures may be associated with changes in fetal growth that elevates the risk for poor health later in life, but few studies have examined the health effects of simultaneous exposure to multiple chemicals. This study aimed to examine the association of gestational exposure to five chemical classes of potential EDCs: phthalates and bisphenol A, perfluoroalkyl substances (PFAS), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) with infant birth weight.
Using data from the Health Outcomes and Measures of Environment (HOME) Study, we examined 272 pregnant women enrolled between 2003-2006. EDC concentrations were quantified in blood and urine samples collected at 16 and 26 weeks gestation. We used Bayesian Hierarchical Linear Models (BHLM) to examine the associations between newborn birth weight and 53 EDCs, 2 organochlorine pesticides (OPPs) and 2 heavy metals.
For a 10-fold increase in chemical concentration, the mean differences in birth weights (95% credible intervals (CI)) were 1 g (-20, 23) for phthalates, -11 g (-52, 34) for PFAS, 0.2 g (-9, 10) for PCBs, -4 g (-30, 22) for PBDEs, and 7 g (-25, 40) for OCPs.
Gestational exposure to phthalates, PFAS, PCBs, PBDEs, OCPs or OPPs had null or small associations with birth weight. Gestational OPP, Pb, and PFAS exposures were most strongly associated with lower birth weight.
孕妇会接触到多种内分泌干扰化学物质（EDCs）。孕期接触EDCs可能与胎儿生长变化有关，从而增加日后健康状况不佳的风险，但很少有研究考察同时接触多种化学物质对健康的影响。本研究旨在探讨孕期接触五类潜在EDCs（邻苯二甲酸盐和双酚A、全氟烷基物质（PFAS）、多氯联苯（PCBs）、多溴二苯醚（PBDEs）和有机氯农药（OCPs））与婴儿出生体重之间的关联。
利用环境健康结果与测量（HOME）研究的数据，我们对2003年至2006年间招募的272名孕妇进行了研究。在妊娠16周和26周时采集的血液和尿液样本中对EDC浓度进行了定量分析。我们使用贝叶斯分层线性模型（BHLM）来考察新生儿出生体重与53种EDCs、2种有机氯农药（OPPs）和2种重金属之间的关联。
化学物质浓度增加10倍时，邻苯二甲酸盐的出生体重平均差异（95%可信区间（CI））为1克（-20，23），PFAS为-11克（-52，34），PCBs为0.2克（-9，10），PBDEs为-4克（-30，22），OCPs为7克（-25，40）。
孕期接触邻苯二甲酸盐、PFAS、PCBs、PBDEs、OCPs或OPPs与出生体重之间的关联不显著或较小。孕期接触OPPs、铅和PFAS与较低出生体重的关联最为密切。
