Oceja Esther, Rodríguez Paula, Jurado María José, Luz Alonso Maria, Del Río Genoveva, Villar María Ángeles, Mediano Olga, Martínez Marian, Juarros Santiago, Merino Milagros, Corral Jaime, Luna Carmen, Kheirandish-Gozal Leila, Gozal David, Durán-Cantolla Joaquín
Domiciliary Hospitalization, Sleep Unit, OSI Araba University Hospital, 01004 Vitoria, Spain.
Research Service and Bioaraba Research Institute, OSI Araba University Hospital, UPV/EHU, 01004 Vitoria, Spain.
Methods Protoc. 2021 Jan 19;4(1):9. doi: 10.3390/mps4010009.
Obstructive sleep apnea (OSA) in children is a prevalent, albeit largely undiagnosed disease associated with a large spectrum of morbidities. Overnight in-lab polysomnography remains the gold standard diagnostic approach, but is time-consuming, inconvenient, and expensive, and not readily available in many places. Simplified Home Respiratory Polygraphy (HRP) approaches have been proposed to reduce costs and facilitate the diagnostic process. However, evidence supporting the validity of HRP is still scarce, hampering its implementation in routine clinical use. The objectives were: Primary; to establish the diagnostic and therapeutic decision validity of a simplified HRP approach compared to PSG among children at risk of OSA. Secondary: (a) Analyze the cost-effectiveness of the HRP versus in-lab PSG in evaluation and treatment of pediatric OSA; (b) Evaluate the impact of therapeutic interventions based on HRP versus PSG findings six months after treatment using sleep and health parameters and quality of life instruments; (c) Discovery and validity of the urine biomarkers to establish the diagnosis of OSA and changes after treatment.
儿童阻塞性睡眠呼吸暂停（OSA）是一种普遍存在但大多未被诊断的疾病，与多种发病情况相关。夜间实验室多导睡眠图仍是金标准诊断方法，但耗时、不便且昂贵，在许多地方难以获得。已提出简化的家庭呼吸多导记录法（HRP）来降低成本并促进诊断过程。然而，支持HRP有效性的证据仍然稀缺，阻碍了其在常规临床应用中的实施。目标如下：主要目标；在有OSA风险的儿童中，确定与多导睡眠图（PSG）相比简化HRP方法的诊断和治疗决策有效性。次要目标：（a）分析HRP与实验室PSG在评估和治疗儿童OSA方面的成本效益；（b）使用睡眠和健康参数以及生活质量工具，评估基于HRP与PSG结果的治疗干预在治疗六个月后的影响；（c）发现尿液生物标志物并验证其在OSA诊断及治疗后变化方面的有效性。
