Falter Tanja, Böschen Sibylle, Schepers Markus, Beutel Manfred, Lackner Karl, Scharrer Inge, Lämmle Bernhard
Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
J Clin Med. 2021 Jan 19;10(2):365. doi: 10.3390/jcm10020365.
Autoimmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening, relapsing disease in which an acquired deficiency of the enzyme ADAMTS13 leads to generalised microvascular thrombosis. Survivors have a high prevalence of depression and impaired cognitive function. The aim of this study was to determine whether life circumstances and personality have an influence on the development and severity of depression and anxiety in iTTP patients and how they impact the quality of life. With validated questionnaires, we examined the prevalence of depression and anxiety symptoms in 104 iTTP patients, as well as parameters of subjective cognitive deficits, quality of life, attitude to life and resilience. iTTP patients had significantly more depressive symptoms ( < 0.001), a tendency to have anxiety disorders ( = 0.035) and a significantly worse cognitive performance ( = 0.008) compared to the controls. Sex, age, physical activity and partnership status had no significant influence on depression, whereas the number of comorbidities did. Lower scores of resilience, attitude to life and quality of life were reported by patients compared to controls. iTTP patients had a high prevalence of depression and anxiety, as well as a more negative attitude to life and low resilience. Resilience correlated negatively with the severity of the depression. Furthermore, quality of life and cognitive performance were significantly reduced.
自身免疫性血栓性血小板减少性紫癜（iTTP）是一种危及生命的复发性疾病，其中获得性酶ADAMTS13缺乏会导致全身性微血管血栓形成。幸存者中抑郁症和认知功能受损的患病率很高。本研究的目的是确定生活环境和个性是否会对iTTP患者的抑郁和焦虑的发生及严重程度产生影响，以及它们如何影响生活质量。通过经过验证的问卷，我们调查了104例iTTP患者的抑郁和焦虑症状患病率，以及主观认知缺陷、生活质量、生活态度和心理弹性的参数。与对照组相比，iTTP患者有明显更多的抑郁症状（<0.001），有患焦虑症的倾向（=0.035），且认知表现明显更差（=0.008）。性别、年龄、身体活动和伴侣状况对抑郁没有显著影响，而合并症的数量有影响。与对照组相比，患者报告的心理弹性、生活态度和生活质量得分较低。iTTP患者抑郁和焦虑的患病率很高，对生活的态度更消极，心理弹性较低。心理弹性与抑郁的严重程度呈负相关。此外，生活质量和认知表现显著降低。
