动脉粥样硬化性血管疾病患者的粘弹性止血测定和血小板功能检测
Viscoelastic Hemostatic Assays and Platelet Function Testing in Patients with Atherosclerotic Vascular Diseases.
作者信息
Samoš Matej, Škorňová Ingrid, Bolek Tomáš, Stančiaková Lucia, Korpallová Barbora, Galajda Peter, Staško Ján, Kubisz Peter, Mokáň Marián
机构信息
Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 59 Martin, Slovakia.
National Centre of Hemostasis and Thrombosis, Department of Hematology and Blood Transfusion, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 036 59 Martin, Slovakia.
出版信息
Diagnostics (Basel). 2021 Jan 19;11(1):143. doi: 10.3390/diagnostics11010143.
Platelets play crucial role in acute vascular atherosclerotic diseases, including myocardial infarction and stroke. Additionally, platelet aggregation is a key target of antiplatelet agents, forming the keystone of pharmacotherapy of various atherosclerotic cardiovascular diseases. Thromboelastography and thromboelastometry, representing currently available viscoelastic hemostatic assays (VHA), are designed as whole blood, real-time analyzers of clot formation and clot resolution. These assays could, in theory, overcome some limitations of currently available platelet function testing assays. This article reviews the current experience with the use of VHA for platelet function testing and for monitoring of the response to antiplatelet therapy.
血小板在急性血管动脉粥样硬化疾病（包括心肌梗死和中风）中发挥着关键作用。此外，血小板聚集是抗血小板药物的关键靶点，构成了各种动脉粥样硬化性心血管疾病药物治疗的基石。血栓弹力图和血栓弹力测定法是目前可用的黏弹性止血检测方法（VHA），被设计为全血实时分析凝血形成和凝血溶解的仪器。从理论上讲，这些检测方法可以克服目前可用的血小板功能检测方法的一些局限性。本文综述了使用VHA进行血小板功能检测以及监测抗血小板治疗反应的当前经验。
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