Post-Graduation in Nutrition Department. Federal Universidade Federal de Pernambuco.
Nutr Hosp. 2021 Apr 19;38(2):281-289. doi: 10.20960/nh.03432.
Background: the dietary pattern that characterizes western diet is strongly associated with metabolic diseases and excess weight, as well as chronic illnesses. Misaligned feeding schedules can lead to or aggravate the development of such conditions. Aim: this study evaluated the influence of dietary composition and/or time-restricted feeding on the anthropometric and biochemical profile of adult rats. Methods: forty male rats, at 60 days of life, were divided into the following groups: Control (C), Restricted Control (RC), Westernized (W), and Restricted Westernized (RW). Results: westernized groups, in spite of a low energy intake (C = 5399 ± 401.2 kcal; RC = 4279.0 ± 476.2 kcal; W = 4302 ± 619.8 kcal; RW = 4081.0 ± 404.4 kcal, p < 0.001), had a higher body weight (C = 404.6 ± 39.1 g; RC = 335.1 ± 36.5 g; W = 488.9 ± 51.2 g; RW = 438.8 ± 36.5 g, p < 0.001) as compared to their paired controls (RC and C) - around 30 % and 20 % more for RW and W, respectively. The westernized diet caused glucose intolerance and mixed hyperlipidemia, characterized by higher concentrations of cholesterol (C = 40.8 ± 7.4 mg/dL; RC = 76.7 ± 10.8 mg/dL; W = 61.3 ± 20.2 mg/dL; RW = 42.2 ± 8.2 mg/dL), LDLc (C = 17.4 ± 7.5 mg/dL; RC = 38.8 ± 7.2 mg/dL ; W = 45.3 ± 15.8 mg/dL; RW = 11.0 ± 5.8 mg/dL), and triacylglycerol (C = 45.2 ± 15.0 mg/dL; RC = 73.2 ± 21.5 mg/dL ; W = 83.6 ± 23.4 mg/dL; RW = 57.5 ± 13.6 mg/dL) in the serum (p < 0.05). Conclusion: the effect of time-restricted feeding on body weight was strongly dependent on diet composition. The glucose tolerance test showed an influence of the circadian cycle phase. Mixed hyperlipidemia varied according to the presence of westernized diet and/or time-restricted food.
以西方饮食为特征的饮食模式与代谢疾病和体重超标以及慢性疾病密切相关。喂养时间安排不当可能导致或加重这些疾病的发展。目的：本研究评估了饮食成分和/或限时喂养对成年大鼠人体测量和生化指标的影响。方法：60 天大的 40 只雄性大鼠被分为以下几组：对照组（C）、限制对照组（RC）、西式饮食组（W）和限制西式饮食组（RW）。结果：尽管西式饮食组的能量摄入较低（C 组为 5399 ± 401.2 kcal；RC 组为 4279.0 ± 476.2 kcal；W 组为 4302 ± 619.8 kcal；RW 组为 4081.0 ± 404.4 kcal，p < 0.001），但体重更高（C 组为 404.6 ± 39.1 g；RC 组为 335.1 ± 36.5 g；W 组为 488.9 ± 51.2 g；RW 组为 438.8 ± 36.5 g，p < 0.001），与配对对照组（RC 和 C）相比，分别高出约 30%和 20%。西式饮食导致葡萄糖耐量受损和混合性高脂血症，其特征是胆固醇（C 组为 40.8 ± 7.4 mg/dL；RC 组为 76.7 ± 10.8 mg/dL；W 组为 61.3 ± 20.2 mg/dL；RW 组为 42.2 ± 8.2 mg/dL）、LDLc（C 组为 17.4 ± 7.5 mg/dL；RC 组为 38.8 ± 7.2 mg/dL；W 组为 45.3 ± 15.8 mg/dL；RW 组为 11.0 ± 5.8 mg/dL）和三酰甘油（C 组为 45.2 ± 15.0 mg/dL；RC 组为 73.2 ± 21.5 mg/dL；W 组为 83.6 ± 23.4 mg/dL；RW 组为 57.5 ± 13.6 mg/dL）在血清中的浓度更高（p < 0.05）。结论：限时喂养对体重的影响强烈依赖于饮食成分。葡萄糖耐量试验显示出昼夜节律相位的影响。混合性高脂血症根据是否存在西式饮食和/或限时喂养而变化。
