Araújo Nathália Cavalcanti de Morais, Souto Vitória Felício, Melo Nathalia Caroline de Oliveira, Amorim Morgana Almeida Cavalcante, Muniz Giselia Santana, Nascimento Elizabeth do
Nutrition Postgraduate Program.Universidade Federal de Pernambuco (UFPE).
Nutrition Department. Universidade Federal de Pernambuco (UFPE).
Nutr Hosp. 2023 Apr 20;40(2):419-427. doi: 10.20960/nh.04213.
Introduction: changes in dietary/energetic composition during the critical period of development (pregnancy/lactation) or even during meal times may contribute to changes in metabolic and behavioral parameters such as feeding behavior. Objective: the study aimed to examine the repercussions of time-restricted feeding on feeding behavior and on some parameters of glycemic and lipemic metabolism of the offspring of adult rats whose mothers were fed a westernized diet during pregnancy and lactation. Methods: initially, 43 male Wistar rats were used. At 60 days of life, the rats were divided into 4 groups: C: control group; RC: control group with time-restricted feeding; W: westernized diet during pregnancy/lactation group; RW: westernized diet group during pregnancy/lactation group with time-restricted feeding. The following parameters were evaluated: behavioral sequence of satiety (BSS), biochemical parameters, and abdominal fat. Results: findings highlighted a high level of abdominal fat in the groups whose mothers were submitted to a westernized diet, as well as hypertriglyceridemia, and clear differences in feed rate and meal length. This study showed that the westernized diet ingested by mothers during pregnancy and lactation induced hyperlipidemia and changes in the feeding behavior of their adult offspring. Conclusions: these changes may be responsible for eating disorders and risk factors for metabolism disturbance-related diseases.
在发育的关键时期（怀孕/哺乳期）甚至用餐时间，饮食/能量组成的变化可能会导致代谢和行为参数的改变，如进食行为。目的：本研究旨在探讨限时进食对成年大鼠后代的进食行为以及血糖和血脂代谢的一些参数的影响，这些成年大鼠的母亲在怀孕和哺乳期喂食西式饮食。方法：最初，使用了43只雄性Wistar大鼠。在60日龄时，将大鼠分为4组：C组：对照组；RC组：限时进食对照组；W组：怀孕/哺乳期西式饮食组；RW组：怀孕/哺乳期西式饮食限时进食组。评估了以下参数：饱腹感行为序列（BSS）、生化参数和腹部脂肪。结果：研究结果突出显示，母亲接受西式饮食的组腹部脂肪含量高，同时伴有高甘油三酯血症，并且在进食速度和进餐时长方面存在明显差异。本研究表明，母亲在怀孕和哺乳期摄入的西式饮食会导致成年后代出现高脂血症和进食行为改变。结论：这些变化可能是饮食失调以及与代谢紊乱相关疾病的风险因素的原因。
