Brown School, Washington University in St. Louis, 1 Brookings Drive, St. Louis, MO, 63130, USA.
Department of Psychology, University of Southern California, 3620 S. McClintock Avenue Rm 520, Los Angeles, CA, 90089, USA.
BMC Public Health. 2021 Jan 21;21(1):179. doi: 10.1186/s12889-021-10202-3.
Youth living with HIV (YLHIV) in Sub-Saharan African (SSA) are less likely to adhere to antiretroviral therapy (ART) and other health-related regimens. As a consequence, YLHIV are not only at risk for health problems and mental health comorbidities, but are also at risk for cognitive deficits, including in areas of memory and executive functioning. The Suubi+Adherence study followed 702 adolescents (10-16 years of age) receiving bolstered standard of care and a family economic empowerment intervention comprising an incentivized youth financial savings account (YSA) augmented with financial literacy training (FLT) and peer mentorship. The study findings pointed to superior short-term viral suppression and positive adolescent health and mental health functioning among participants receiving the intervention. The original group of adolescents who received Suubi+Adherence are now transitioning into young adulthood. This paper presents a protocol for the follow-up phase titled Suubi+Adherence Round 2.
The original cohort in Suubi+Adherence will be tracked for an additional five years (2020-2025). Specifically, the long term follow-up will allow to: 1) ascertain the extent to which the short term outcomes identified in the first 6 years of the intervention are maintained as the same group transitions through young adulthood; and 2) address new scientific questions regarding ART adherence; HIV care engagement; protective health behaviors; and the potential of FEE to mitigate the development of HIV-associated neurocognitive disorders in YLHIV. Additionally, the team examines the potential mechanisms through which the observed long-term outcomes happen. Moreover, the Suubi+Adherence-Round 2 adds a qualitative component and extends the cost effectiveness component.
Guided by asset and human development theories, Suubi+Adherence-R2 will build on the recently concluded Suubi+Adherence study to conduct one of the largest and longest running studies of YLHIV in SSA as they transition into young adulthood. The study will address new scientific questions regarding long-term ART adherence, HIV care engagement, protective health behaviors, and the potential of FEE to mitigate the development of HIV-associated neurocognitive disorders in YLHIV. The findings may inform efforts to improve HIV care among Uganda's YLHIV, with potential replicability in other low-resource countries.
ClinicalTrials.gov , ID: NCT01790373.
撒哈拉以南非洲（SSA）的青年艾滋病毒感染者（YLHIV）不太可能坚持接受抗逆转录病毒疗法（ART）和其他与健康相关的治疗方案。因此，YLHIV 不仅面临健康问题和心理健康合并症的风险，而且还面临认知缺陷的风险，包括记忆和执行功能领域。Suubi+Adherence 研究跟踪了 702 名接受强化标准护理和家庭经济赋权干预的青少年（10-16 岁），该干预措施包括一个有激励的青年储蓄账户（YSA），辅以金融扫盲培训（FLT）和同伴指导。研究结果表明，接受干预的参与者在短期病毒抑制和青少年健康和心理健康功能方面表现出更好的效果。最初接受 Suubi+Adherence 的青少年群体现在已经过渡到成年早期。本文介绍了后续阶段的方案，名为 Suubi+Adherence Round 2。
Suubi+Adherence 中的原始队列将再跟踪五年（2020-2025 年）。具体来说，长期随访将使我们能够：1）确定随着同一组过渡到成年早期，干预的前 6 年确定的短期结果在多大程度上得以维持；2）解决关于 ART 坚持、HIV 护理参与、保护健康行为以及 FEE 缓解 YLHIV 中与 HIV 相关的神经认知障碍发展的潜力的新科学问题。此外，该团队还研究了观察到的长期结果发生的潜在机制。此外，Suubi+Adherence-Round 2 添加了定性部分并扩展了成本效益部分。
受资产和人类发展理论的指导，Suubi+Adherence-R2 将基于最近结束的 Suubi+Adherence 研究，对撒哈拉以南非洲的 YLHIV 过渡到成年早期的最大和最长时间的研究之一进行研究。该研究将解决关于长期 ART 坚持、HIV 护理参与、保护健康行为以及 FEE 缓解 YLHIV 中与 HIV 相关的神经认知障碍发展的潜力的新科学问题。研究结果可能会为改善乌干达 YLHIV 的 HIV 护理工作提供信息，并在其他资源匮乏的国家具有潜在的可复制性。
ClinicalTrials.gov，ID：NCT01790373。
