Department of Otorhinolaryngology - Head and Neck Surgery, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Department of Nuclear Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
J Laryngol Otol. 2021 Jan;135(1):50-56. doi: 10.1017/S0022215120002571. Epub 2021 Jan 22.
To detect whether the adverse effects of post-operative radioactive iodine therapy following differentiated thyroid cancer on smell, taste and nasal functions were associated with radioactive iodine dose.
Fifty-one patients who had undergone total thyroidectomy because of differentiated thyroid cancer were divided into two groups depending on the post-operative radioactive iodine therapy dose: low dose group (50 mCi; 21 patients) and high dose group (100-150 mCi; 30 patients). The Sniffin' Sticks smell test, the Taste Strips test and the 22-item Sino-Nasal Outcome Test were performed on all patients one week before therapy, and at two months and one year following therapy.
Statistically significant differences were detected in the Sniffin' Sticks test results, total odour scores, total taste scores and Sino-Nasal Outcome Test results between the assessment time points. There was no statistically significant difference between the low and high dose groups in terms of odour, taste or Sino-Nasal Outcome Test scores either before or after therapy.
Radioactive iodine therapy has some short- and long-term adverse effects on nasal functions and taste and odour sensations, which affect quality of life. These effects are not dose-dependent.
检测分化型甲状腺癌术后放射性碘治疗对嗅觉、味觉和鼻功能的不良影响是否与放射性碘剂量有关。
51 例因分化型甲状腺癌行甲状腺全切除术的患者，根据术后放射性碘治疗剂量分为低剂量组（50mCi；21 例）和高剂量组（100-150mCi；30 例）。所有患者在治疗前一周、治疗后 2 个月和 1 年进行嗅觉测试（Sniffin' Sticks 测试）、味觉测试（Taste Strips 测试）和 22 项鼻-鼻窦结局测试（Sino-Nasal Outcome Test）。
在评估时间点，Sniffin' Sticks 测试结果、总嗅觉评分、总味觉评分和 Sino-Nasal Outcome Test 结果存在统计学差异。治疗前后，低剂量组和高剂量组在嗅觉、味觉或 Sino-Nasal Outcome Test 评分方面均无统计学差异。
放射性碘治疗对鼻功能以及味觉和嗅觉感知有短期和长期的不良影响，影响生活质量。这些影响与剂量无关。
