分泌促卵泡生成素和促黄体生成素的垂体腺瘤。

FSH and LH secreting pituitary adenoma.

作者信息

Demura R, Kubo O, Demura H, Shizume K

出版信息

J Clin Endocrinol Metab. 1977 Oct;45(4):653-7. doi: 10.1210/jcem-45-4-653.

Abstract

A case of FSH and LH secreting pituitary adenoma which was not preceded by hypogonadism is reported. The patient, a 50-year-old man, was admitted to the hospital because of left temporal hemianopsia. No clinical evidence of hypogonadism was demonstrated. Endocrine studies of hypogonadism was demonstrated. Endocrine studies revealed markedly elevated plasma FSH of 295 mIU/ml and slightly elevated LH of 35 mIU/ml (2nd IRP-HMG). Plasma FSH and LH did not respond to the administration of LRF, conjugated equine estrogens and testosterone. Plasma testosterone was 691 ng/dl and rose nromally after pregnant mare's serum gonadotropin. Sperm count was 46 X 10(6)/ml. Transfrontal hypophysectomy was followed by a marked decrease of both FSH (to 19mIU/ml) and LH (to 22 mIU/ml). Histologic examination of the tumor revealed 90% chromophobe cells and 10% slightly eosinophilic cells. Two sizes of secretory granules were demonstrated. Tumor cells in tissue culture secreted both FSH and LH.

摘要

报告一例未伴有性腺功能减退的促卵泡生成素（FSH）和促黄体生成素（LH）分泌型垂体腺瘤病例。患者为一名50岁男性，因左侧颞叶偏盲入院。未发现性腺功能减退的临床证据。性腺功能减退的内分泌检查得以证实。内分泌研究显示血浆FSH显著升高至295 mIU/ml，LH轻度升高至35 mIU/ml（第二国际参考制剂-人绝经期促性腺激素）。血浆FSH和LH对注射促性腺激素释放激素（LRF）、结合马雌激素和睾酮均无反应。血浆睾酮为691 ng/dl，注射孕马血清促性腺激素后正常升高。精子计数为46×10⁶/ml。经额垂体切除术之后，FSH（降至19 mIU/ml）和LH（降至22 mIU/ml）均显著下降。肿瘤组织学检查显示90%为嫌色细胞，10%为轻度嗜酸性细胞。发现了两种大小的分泌颗粒。组织培养中的肿瘤细胞分泌FSH和LH。