Department of Neonatology, Hospital General Universitario Gregorio Marañón and Complutense University of Madrid, Madrid, Spain;
Neonatology Service, Department of Pediatrics, Hospital Central Universitario de Asturias, Oviedo, Spain.
Pediatrics. 2021 Feb;147(2). doi: 10.1542/peds.2020-015065.
To describe neonatal and maternal characteristics of the largest prospective cohort of newborns from mothers with coronavirus disease 2019 (COVID-19), the data of which were prospectively collected from the nationwide registry of the Spanish Society of Neonatology.
Between March 8, 2020, and May 26, 2020, the data of 503 neonates born to 497 mothers diagnosed with COVID-19 during pregnancy or at the time of delivery were collected by 79 hospitals throughout Spain.
Maternal symptoms were similar to that of the general population, with 5% of severe forms. In 45.8% of asymptomatic women at the time of delivery, severe acute respiratory syndrome coronavirus 2 infection was detected because of recommendations established in Spain to perform COVID-19 screening in all women admitted to the hospital for labor. The rate of preterm deliveries was 15.7% and of cesarean deliveries, 33%. The most common diagnostic test was detection of viral RNA by polymerase chain reaction of nasopharyngeal swabs at a median age of 3 hours after delivery (1-12 hours). Almost one-half of neonates were left skin-to-skin after delivery, and delayed clamping of umbilical cords was performed in 43% of neonates. Also, 62.3% of asymptomatic neonates were managed with rooming-in. Maternal milk was received by 76.5% of neonates, 204 of them as exclusive breastfeeding.
The current study indicates that there is no need for separation of mothers from neonates, allowing delayed cord clamping and skin-to-skin contact along with maintenance of breastfeeding in a high percentage of newborns from mothers with COVID-19.
描述来自新型冠状病毒病（COVID-19）母亲的最大前瞻性新生儿队列的新生儿和产妇特征，这些数据是从西班牙新生儿学会的全国注册处前瞻性收集的。
2020 年 3 月 8 日至 2020 年 5 月 26 日，西班牙 79 家医院共收集了 503 例由确诊为 COVID-19 的母亲分娩的新生儿的数据，这些母亲中有 497 例在怀孕期间或分娩时确诊。
产妇症状与一般人群相似，有 5%为严重症状。在分娩时无症状的 45.8%女性中，由于西班牙建议对所有因分娩住院的女性进行 COVID-19 筛查，检测到严重急性呼吸综合征冠状病毒 2 感染。早产率为 15.7%，剖宫产率为 33%。最常见的诊断检测是通过聚合酶链反应检测鼻咽拭子中的病毒 RNA，中位年龄为分娩后 3 小时（1-12 小时）。几乎有一半的新生儿在分娩后立即进行皮肤接触，43%的新生儿脐带延迟结扎。此外，62.3%的无症状新生儿与母亲同室。76.5%的新生儿接受了母亲的母乳，其中 204 名新生儿进行了纯母乳喂养。
目前的研究表明，没有必要将母亲与新生儿分开，可以允许延迟脐带结扎和皮肤接触，并在很大比例的 COVID-19 母亲的新生儿中保持母乳喂养。
