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Structure-based design and analysis of SuFEx chemical probes.基于结构的硫氟交换（SuFEx）化学探针的设计与分析
RSC Med Chem. 2020 Jan 6;11(1):10-17. doi: 10.1039/c9md00542k. eCollection 2020 Jan 1.
2
Covalent drug discovery using sulfur(VI) fluoride exchange warheads.利用六氟硫鎓盐作为亲电氟化试剂的共价药物研发。
Expert Opin Drug Discov. 2023 Jul;18(7):725-735. doi: 10.1080/17460441.2023.2218642. Epub 2023 May 27.
3
The proximity-enabled sulfur fluoride exchange reaction in the protein context.蛋白质环境中基于邻近效应的硫氟交换反应。
Chem Sci. 2023 Jun 20;14(29):7913-7921. doi: 10.1039/d3sc01921g. eCollection 2023 Jul 26.
4
Advances in the construction of diverse SuFEx linkers.多样化的硫氟交换（SuFEx）连接子构建方面的进展。
Natl Sci Rev. 2023 Apr 29;10(6):nwad123. doi: 10.1093/nsr/nwad123. eCollection 2023 Jun.
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Chemical and biology of sulfur fluoride exchange (SuFEx) click chemistry for drug discovery.硫氟交换（SuFEx）点击化学的化学和生物学在药物发现中的应用。
Bioorg Chem. 2023 Jan;130:106227. doi: 10.1016/j.bioorg.2022.106227. Epub 2022 Oct 30.
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Cereblon covalent modulation through structure-based design of histidine targeting chemical probes.通过基于结构设计靶向组氨酸的化学探针实现对 Cereblon 的共价修饰
RSC Chem Biol. 2022 Jul 8;3(9):1105-1110. doi: 10.1039/d2cb00078d. eCollection 2022 Aug 31.
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Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF Hub.多维 SuFEx 点击化学：从 SOF 枢纽出发的多样模块的顺序硫（VI）氟化物交换连接。
Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2903-2908. doi: 10.1002/anie.201611048. Epub 2017 Feb 6.
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Discovering covalent inhibitors of protein-protein interactions from trillions of sulfur(VI) fluoride exchange-modified oligonucleotides.从万亿个硫（VI）氟化物交换修饰的寡核苷酸中发现蛋白-蛋白相互作用的共价抑制剂。
Nat Chem. 2023 Dec;15(12):1705-1714. doi: 10.1038/s41557-023-01304-z. Epub 2023 Aug 31.
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Sulfur-fluoride exchange (SuFEx)-enabled lead discovery of AChE inhibitors by fragment linking strategies.通过片段连接策略的硫氟交换（SuFEx）实现的乙酰胆碱酯酶抑制剂的先导发现。
Eur J Med Chem. 2023 Sep 5;257:115502. doi: 10.1016/j.ejmech.2023.115502. Epub 2023 May 18.
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Ex situ Generation of Thiazyl Trifluoride (NSF ) as a Gaseous SuFEx Hub.体外生成三氟硫鎓盐（NSF）作为气体 SuFEx 中心。
Angew Chem Int Ed Engl. 2023 Jul 17;62(29):e202305093. doi: 10.1002/anie.202305093. Epub 2023 Jun 12.
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Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation.鉴定对金黄色葡萄球菌毒力和生物膜形成至关重要的丝氨酸水解酶的共价抑制剂。
Nat Commun. 2025 May 30;16(1):5046. doi: 10.1038/s41467-025-60367-3.
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Advances in sulfonyl exchange chemical biology: expanding druggable target space.磺酰基交换化学生物学的进展：拓展可成药靶点空间
Chem Sci. 2025 May 6;16(23):10119-10140. doi: 10.1039/d5sc02647d. eCollection 2025 Jun 11.
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Proximity-induced SuFEx increases the potency of cytosolic nucleotidase inhibitors and reveals a rare example of covalently targeted histidine.邻近诱导的硫氟交换反应增强了胞质核苷酸酶抑制剂的效力，并揭示了一个罕见的共价靶向组氨酸的例子。
RSC Chem Biol. 2025 Apr 23. doi: 10.1039/d5cb00005j.
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Covalent-fragment screening identifies selective inhibitors of multiple Staphylococcus aureus serine hydrolases important for growth and biofilm formation.共价片段筛选鉴定出对金黄色葡萄球菌生长和生物膜形成重要的多种丝氨酸水解酶的选择性抑制剂。
Res Sq. 2024 Dec 13:rs.3.rs-5494070. doi: 10.21203/rs.3.rs-5494070/v1.
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Harnessing Oxetane and Azetidine Sulfonyl Fluorides for Opportunities in Drug Discovery.利用氧杂环丁烷和氮杂环丁烷磺酰氟在药物研发中的机遇。
J Am Chem Soc. 2024 Dec 25;146(51):35377-35389. doi: 10.1021/jacs.4c14164. Epub 2024 Dec 12.
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SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex.SuFEx 化学实现了 280 kDa 18 亚基孔形成复合物的共价组装。
J Am Chem Soc. 2024 Sep 11;146(36):25047-25057. doi: 10.1021/jacs.4c07920. Epub 2024 Aug 27.
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Palladium-Catalyzed Addition of Aryl Halides to -Sulfinylamines for the Synthesis of Sulfinamides.钯催化芳基卤化物与亚磺酰胺加成反应合成亚磺酰胺
J Am Chem Soc. 2024 Jul 24;146(29):19690-19695. doi: 10.1021/jacs.4c06726. Epub 2024 Jul 12.
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Ionic Liquids Containing the Sulfonyl Fluoride Moiety: Integrating Chemical Biology with Materials Design.含磺酰氟基团的离子液体：将化学生物学与材料设计相结合。
J Electrochem Soc. 2023;170(6). doi: 10.1149/1945-7111/acdeac. Epub 2023 Jun 23.
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Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.基于结构的共价 VHL 靶向磺酰氟 PROTACs 的设计与优化。
J Med Chem. 2024 Mar 28;67(6):4641-4654. doi: 10.1021/acs.jmedchem.3c02123. Epub 2024 Mar 13.
10
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.开发磺酰氟化学探针以推动对cereblon调节剂的发现。
RSC Med Chem. 2024 Jan 9;15(2):607-611. doi: 10.1039/d3md00652b. eCollection 2024 Feb 21.
本文引用的文献
1
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.基于芳基氟硫酸盐的赖氨酸共价泛凋亡蛋白（IAP）拮抗剂细胞效力。
J Med Chem. 2019 Oct 24;62(20):9188-9200. doi: 10.1021/acs.jmedchem.9b01108. Epub 2019 Oct 8.
2
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.SuFEx 使能的人中性粒细胞弹性蛋白酶共价抑制剂的无偏倚发现。
Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18808-18814. doi: 10.1073/pnas.1909972116. Epub 2019 Sep 4.
3
Expanding chemogenomic space using chemoproteomics.利用化学生物组学拓展化学基因组空间。
Bioorg Med Chem. 2019 Aug 1;27(15):3451-3453. doi: 10.1016/j.bmc.2019.06.022. Epub 2019 Jun 13.
4
Quantifying drug-target engagement in live cells using sulfonyl fluoride chemical probes.使用磺酰氟化学探针定量活细胞中的药物-靶点相互作用。
Methods Enzymol. 2019;622:201-220. doi: 10.1016/bs.mie.2019.02.010. Epub 2019 Mar 9.
5
Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A Receptor.G蛋白偶联受体共价配体的开发：以人腺苷A受体为例
J Med Chem. 2019 Apr 11;62(7):3539-3552. doi: 10.1021/acs.jmedchem.8b02026. Epub 2019 Mar 28.
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Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A Receptor.别构药物配体在腺苷 A 受体中结合的结构基础。
Sci Rep. 2018 Nov 15;8(1):16836. doi: 10.1038/s41598-018-35266-x.
7
Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry.用于特定和多靶标交联质谱的邻近增强型 SuFEx 化学交联剂。
Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):11162-11167. doi: 10.1073/pnas.1813574115. Epub 2018 Oct 15.
8
Emerging Utility of Fluorosulfate Chemical Probes.氟代硫酸盐化学探针的新兴应用
ACS Med Chem Lett. 2018 Jun 27;9(7):584-586. doi: 10.1021/acsmedchemlett.8b00276. eCollection 2018 Jul 12.
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Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area.蛋白质-蛋白质相互作用（PPIs）抑制剂：支架选择和埋藏表面积分析。
Curr Opin Chem Biol. 2018 Jun;44:75-86. doi: 10.1016/j.cbpa.2018.06.004. Epub 2018 Jun 13.
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Reactive Chemical Probes: Beyond the Kinase Cysteinome.反应性化学探针：超越蛋白激酶半胱氨酸组。
Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9220-9223. doi: 10.1002/anie.201802693. Epub 2018 Jun 12.
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