Brackett Sara M, Cox Karlie E, Barlock Samantha L, Huggins William M, Ackart David F, Bassaraba Randall J, Melander Roberta J, Melander Christian
Department of Chemistry and Biochemistry , University of Notre Dame , Notre Dame , IN 46556 , USA . Email:
Department of Chemistry , North Carolina State University , Raleigh , NC 27695 , USA.
RSC Med Chem. 2019 Dec 16;11(1):92-97. doi: 10.1039/c9md00466a. eCollection 2020 Jan 1.
The formation of bacterial biofilms significantly decreases the efficacy of antibiotic treatments. Herein, we've investigated the antibiofilm properties of the natural product meridianin D and a library of analogues against . As a result, we discovered several analogues that both inhibit and disperse biofilms.
细菌生物膜的形成显著降低了抗生素治疗的效果。在此，我们研究了天然产物子午线菌素D及其一系列类似物对……的抗生物膜特性。结果，我们发现了几种既能抑制又能分散生物膜的类似物。
