Department of Infectious Diseases, Imperial College Healthcare NHS Trust, London, United Kingdom.
Department of Infectious Disease, Imperial College London, London, United Kingdom.
Med Mycol. 2021 Apr 6;59(4):404-408. doi: 10.1093/mmy/myaa113.
Prompt and reliable diagnosis of invasive pulmonary aspergillosis (IPA) is essential for early initiation of antifungal therapy. We evaluated bronchoalveolar lavage (BAL) fluid IMMY Sona Aspergillus lateral-flow assay (IMMY LFA) in 92 individuals with suspected pulmonary infection. Sensitivity and specificity (vs. host factor but no IPA) of BAL IMMY LFA for diagnosis of IPA in individuals with any European Organisation for Research and Treatment of Cancer-defied "host factor" were 67% and 85%, respectively. Performance appeared better in individuals with renal transplantation (100%, 100%), compared to those with hematological malignancy and/or allogenic stem cell transplantation (70%, 78%). We found BAL IMMY LFA to be a convenient and useful addition to our diagnostic armory for IPA.
We evaluated a new test for diagnosing invasive pulmonary aspergillosis from bronchoscopy samples. We tested 92 people and found that it was 67% sensitive and 85% specific (compared to diagnosis according to a set of internationally recognised criteria). We found this test convenient and useful.
快速可靠地诊断侵袭性肺曲霉病（IPA）对于早期开始抗真菌治疗至关重要。我们评估了 92 名疑似肺部感染患者的支气管肺泡灌洗液（BAL）中 IMMY Sona Aspergillus 侧向流动检测（IMMY LFA）。BAL IMMY LFA 对任何欧洲癌症研究和治疗组织定义的“宿主因素”但无 IPA 的个体的 IPA 诊断的敏感性和特异性（与宿主因素但无 IPA）分别为 67%和 85%。在肾移植（100%，100%）患者中，其性能优于血液系统恶性肿瘤和/或异基因干细胞移植（70%，78%）患者。我们发现 BAL IMMY LFA 是 IPA 诊断的一种方便且有用的附加方法。
我们评估了一种从支气管镜样本中诊断侵袭性肺曲霉病的新检测方法。我们对 92 人进行了测试，发现其敏感性为 67%，特异性为 85%（与根据一套国际公认的标准进行的诊断相比）。我们发现该测试方便且有用。
