Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Dermatol Ther. 2021 Mar;34(2):e14794. doi: 10.1111/dth.14794. Epub 2021 Feb 4.
Drug-induced acanthosis nigricans is an uncommon subtype of acanthosis nigricans and the data on this topic is not well understood by clinicians as it is presently limited in the literature. Previous reports of drug-induced acanthosis nigricans have simply consisted of a list of drugs possibly implicated in causing acanthosis nigricans. Several drugs listed are based on single case reports without biopsy confirmation, report of clearing on stopping the drug or reporting on whether acanthosis nigricans recurred with drug rechallenge. A comprehensive literature search was conducted using PubMed, EMBASE(Ovid), Cochrane Library, Scopus, and Web of Science electronic databases. The authors screened the initial result of the search strategy by title and abstract using the following inclusion criteria: eligible studies included those with patients who developed acanthosis nigricans secondary to a drug. This study is the first to comprehensively review the drugs that have been implicated in the development of acanthosis nigricans. A total of 38 studies were included in the systematic review, and a total of 13 acanthosis nigricans inducing drugs were identified. Nicotinic acid and insulin were the two most significant drugs that were reported to cause acanthosis nigricans. By using the results of this study, we created a revised classification system of drug-induced acanthosis nigricans which can be used as a concise framework for clinicians to refer to.
药物诱导性黑棘皮病是黑棘皮病的一种不常见亚型，由于目前文献中对此类疾病的研究有限，临床医生对此了解甚少。先前关于药物诱导性黑棘皮病的报告仅仅列出了一些可能导致黑棘皮病的药物。列出的几种药物仅基于单个病例报告，没有活检确认、停药后是否清除或是否在药物再挑战时复发的报告。本研究使用 PubMed、EMBASE（Ovid）、Cochrane 图书馆、Scopus 和 Web of Science 电子数据库进行了全面的文献检索。作者通过标题和摘要筛选了搜索策略的初始结果，使用了以下纳入标准：合格的研究包括因药物而继发黑棘皮病的患者。这是第一项全面综述药物诱发黑棘皮病的研究。系统评价共纳入 38 项研究，共确定了 13 种诱发黑棘皮病的药物。烟酸和胰岛素是报告中导致黑棘皮病的两种最重要的药物。通过使用本研究的结果，我们创建了一个修订的药物诱导性黑棘皮病分类系统，可作为临床医生参考的简洁框架。
