UCL Cancer Institute, University College London, London, UK.
School of Engineering, Newcastle University, Newcastle upon Tyne, UK.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jul;13(4):e1699. doi: 10.1002/wnan.1699. Epub 2021 Jan 22.
Transdermal biosensors for the real-time and continuous detection and monitoring of target molecules represent an intriguing pathway for enhancing health outcomes in a cost-effective and non-invasive fashion. Many transdermal biosensor devices contain microneedles and other miniaturized components. There remains an unmet clinical need for microneedle transdermal biosensors to obtain a more accurate, rapid, and reliable insight into the real-time monitoring of disease. The ability to monitor biomarkers at an intradermal molecular level in a non-invasive manner remains the next technological gap to solve real-world clinical problems. The emergence of the two-dimensional material graphene with unique material properties and the ability to quantify analytes and physiological status can enable the detection of critical biomarkers indicative of human disease. The development of a user-friendly, affordable, and non-invasive transdermal biosensing device for continuous and personalized monitoring of target molecules could be beneficial for many patients. This focus article considers the use of graphene-based transdermal biosensors for health monitoring, evaluation of these sensors for glucose and hydrogen peroxide detection via in vitro, in vivo, and ex vivo studies, recent technological innovations, and potential challenges. This article is categorized under: Diagnostic Tools > Biosensing.
用于实时和连续检测与监测目标分子的经皮生物传感器代表了一种很有前途的方法，可以以具有成本效益且非侵入性的方式来改善健康结果。许多经皮生物传感器设备包含微针和其他微型组件。临床仍然需要一种未满足的需求，即需要微针经皮生物传感器来更准确、快速和可靠地实时监测疾病。以非侵入性方式在皮内分子水平监测生物标志物的能力仍然是下一个需要解决的技术差距，以解决现实世界中的临床问题。具有独特材料特性和定量分析物和生理状态能力的二维材料石墨烯的出现，可以实现对指示人类疾病的关键生物标志物的检测。开发一种用户友好、价格合理且非侵入性的经皮生物传感装置，用于对目标分子进行连续和个性化监测，可能对许多患者有益。本文重点讨论了基于石墨烯的经皮生物传感器在健康监测中的应用，评估了这些传感器在体外、体内和离体研究中用于葡萄糖和过氧化氢检测的性能，介绍了最近的技术创新和潜在挑战。本文属于以下分类：诊断工具 > 生物传感。
