Inchingolo Francesco, Inchingolo Angelo Michele, Latini Giulia, Palmieri Giulia, Di Pede Chiara, Trilli Irma, Ferrante Laura, Inchingolo Alessio Danilo, Palermo Andrea, Lorusso Felice, Scarano Antonio, Dipalma Gianna
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
College of Medicine and Dentistry, Birmingham B4 6BN, UK.
Materials (Basel). 2023 Sep 20;16(18):6293. doi: 10.3390/ma16186293.
The current review aims to provide an overview of the most recent research in the last 10 years on the potentials of graphene in the dental surgery field, focusing on the potential of graphene oxide (GO) applied to implant surfaces and prosthetic abutment surfaces, as well as to the membranes and scaffolds used in Guided Bone Regeneration (GBR) procedures. "Graphene oxide" and "dental surgery" and "dentistry" were the search terms utilized on the databases Scopus, Web of Science, and Pubmed, with the Boolean operator "AND" and "OR". Reviewers worked in pairs to select studies based on specific inclusion and exclusion criteria. They included animal studies, clinical studies, or case reports, and in vitro and in vivo studies. However, they excluded systematic reviews, narrative reviews, and meta-analyses. Results: Of these 293 studies, 19 publications were included in this review. The field of graphene-based engineered nanomaterials in dentistry is expanding. Aside from its superior mechanical properties, electrical conductivity, and thermal stability, graphene and its derivatives may be functionalized with a variety of bioactive compounds, allowing them to be introduced into and improved upon various scaffolds used in regenerative dentistry. This review presents state-of-the-art graphene-based dental surgery applications. Even if further studies and investigations are still needed, the GO coating could improve clinical results in the examined dental surgery fields. Better osseointegration, as well as increased antibacterial and cytocompatible qualities, can benefit GO-coated implant surgery. On bacterially contaminated implant abutment surfaces, the CO coating may provide the optimum prospects for soft tissue sealing to occur. GBR proves to be a safe and stable material, improving both bone regeneration when using GO-enhanced graft materials as well as biocompatibility and mechanical properties of GO-incorporated membranes.
本综述旨在概述过去10年中石墨烯在牙科手术领域潜力的最新研究，重点关注氧化石墨烯（GO）应用于种植体表面和修复基台表面，以及引导骨再生（GBR）手术中使用的膜和支架的潜力。在Scopus、Web of Science和Pubmed数据库中使用搜索词“氧化石墨烯”、“牙科手术”和“牙科”，并使用布尔运算符“AND”和“OR”。评审人员成对工作，根据特定的纳入和排除标准选择研究。这些研究包括动物研究、临床研究或病例报告，以及体外和体内研究。然而，他们排除了系统评价、叙述性综述和荟萃分析。结果：在这293项研究中，本综述纳入了19篇出版物。牙科中基于石墨烯的工程纳米材料领域正在不断扩大。除了具有优异的机械性能、导电性和热稳定性外，石墨烯及其衍生物还可以用多种生物活性化合物进行功能化，使其能够引入并改进再生牙科中使用的各种支架。本综述介绍了基于石墨烯的牙科手术的最新应用。即使仍需要进一步的研究和调查，但GO涂层可以改善所研究的牙科手术领域的临床结果。更好的骨整合以及增强的抗菌和细胞相容性质量，可使GO涂层种植手术受益。在受细菌污染的种植体基台表面，CO涂层可能为软组织密封提供最佳前景。GBR被证明是一种安全稳定的材料，在使用GO增强移植物材料时可改善骨再生，以及GO掺入膜的生物相容性和机械性能。
