Ningbo Research Institute, Zhejiang University, Ningbo, China.
College of Biosystems Engineering and Food Science, Zhejiang University, Beijing, China.
Crit Rev Food Sci Nutr. 2022;62(14):3979-3989. doi: 10.1080/10408398.2021.1874287. Epub 2021 Jan 22.
Hyperuricemia (HUA) is a metabolic disorder caused by abnormal uric acid (UA) metabolism, which is a complex physiological process involving multiple organs (liver, kidney, and intestine). Although UA metabolism in the liver and kidneys has been elucidated, only a few studies have focused on the process in the intestine. With our growing knowledge of the effects of gut microorganisms on health, the gut microbiota has been identified as a new target for HUA treatment. In this review, the relationship between HUA and the gut microbiota is elucidated, and anti-hyperuricemia mechanisms targeting the intestine are discussed, such as the promotion of purine and UA catabolism by the gut microbiota, increases in UA excretion by the gut microbiota and its metabolites, regulation of UA absorption or secretion in the intestinal tract by certain transporters, and the intestinal inflammatory response to the gut microbiota. Additionally, probiotics ( and ) and prebiotics (polyphenols, peptides, and phytochemicals) with UA-lowering effects targeting the intestinal tract are summarized, providing reference and guidance for further research.
高尿酸血症（HUA）是由尿酸（UA）代谢异常引起的代谢性疾病，这是一个涉及多个器官（肝脏、肾脏和肠道）的复杂生理过程。虽然肝脏和肾脏中的 UA 代谢已经阐明，但只有少数研究关注肠道中的这一过程。随着我们对肠道微生物群对健康影响的认识不断增加，肠道微生物群已被确定为 HUA 治疗的新靶点。在这篇综述中，阐明了 HUA 与肠道微生物群的关系，并讨论了针对肠道的抗高尿酸血症机制，例如肠道微生物群促进嘌呤和 UA 代谢、增加 UA 排泄及其代谢物、某些转运蛋白调节 UA 在肠道中的吸收或分泌，以及肠道微生物群引起的肠道炎症反应。此外，还总结了针对肠道的具有降 UA 作用的益生菌（ 和 ）和益生元（多酚、肽和植物化学物质），为进一步研究提供了参考和指导。
