Cao Jiayuan, Wang Ting, Liu Yisuo, Zhou Wei, Hao Haining, Liu Qiqi, Yin Boxing, Yi Huaxi
College of Food Science and Engineering, Ocean University of China, Qingdao, 266000, China.
Yangzhou University Healthy source Dairy Co., LTD., Yangzhou, 225002, China.
Food Funct. 2023 Apr 3;14(7):3259-3268. doi: 10.1039/d2fo03701g.
Hyperuricemia (HUA) is a systemic disease characterized by a disorder of purine metabolism and an abnormal increase in the serum level of uric acid (UA). Probiotics can exert potential therapeutic benefits against some metabolic diseases by regulating the intestinal microbiota. F40-4 with UA-lowering activity of 87.40% was screened using purine as the target . The UA-lowering activity of F40-4 was further explored in a mouse model of HUA . F40-4 could downregulate serum levels of UA, blood urea nitrogen, creatinine, and xanthine oxidase by 40.84%, 11.61%, 57.66%, and 41.79%, respectively. F40-4 restored organ damage, and adjusted enzyme activity and transporter expression to promote the metabolic level of UA. In addition, F40-4 could reshape the gut microbiota and suppress inflammation to ameliorate HUA. An increment in intestinal UA excretion was documented. These findings suggest that F40-4 might serve as a potential probiotic for the prevention and treatment of HUA.
高尿酸血症（HUA）是一种以嘌呤代谢紊乱和血清尿酸（UA）水平异常升高为特征的全身性疾病。益生菌可通过调节肠道微生物群对某些代谢性疾病发挥潜在的治疗作用。以嘌呤为靶点筛选出UA降低活性为87.40%的F40-4。在HUA小鼠模型中进一步探究F40-4的降尿酸活性。F40-4可分别使血清UA、血尿素氮、肌酐和黄嘌呤氧化酶水平下调40.84%、11.61%、57.66%和41.79%。F40-4修复器官损伤，调节酶活性和转运蛋白表达以提高UA的代谢水平。此外，F40-4可重塑肠道微生物群并抑制炎症以改善HUA。有记录显示肠道UA排泄增加。这些发现表明F40-4可能是预防和治疗HUA的潜在益生菌。
