Biopharmaceutic study and efficacy of natural and derivatives flavanones formulations.

The development and characterization of nanostructured flavanone formulations (FF) of extracted from and , , and derivatives by structural modification of as anti-inflammatory candidates for topical treatment of local inflammation. The FF were physicochemical characterized and the behavior release, permeation and, anti-inflammatory efficacy in the rat model were studied. The FF revealed sustained drug release and showed slow drug penetration in human skin. The FF reduced inflammation in comparison with the standard formulation. The FF could be effective systems for the delivery and controlled release of flavanones on the skin, and the chemical modification of lead molecule improved the efficacy.