Department of Pharmacy & Pharmaceutical Technology & Physical Chemistry, Faculty of Pharmacy & Food Science, University of Barcelona, Av. Joan XXIII 29-31, Barcelona 08028, Spain.
Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma del Estado de Morelos; Av. Universidad 1001, Cuernavaca, Morelos, México.
Nanomedicine (Lond). 2021 Feb;16(3):205-220. doi: 10.2217/nnm-2020-0368. Epub 2021 Jan 22.
The development and characterization of nanostructured flavanone formulations (FF) of extracted from and , , and derivatives by structural modification of as anti-inflammatory candidates for topical treatment of local inflammation. The FF were physicochemical characterized and the behavior release, permeation and, anti-inflammatory efficacy in the rat model were studied. The FF revealed sustained drug release and showed slow drug penetration in human skin. The FF reduced inflammation in comparison with the standard formulation. The FF could be effective systems for the delivery and controlled release of flavanones on the skin, and the chemical modification of lead molecule improved the efficacy.
从 、 、 、 及其衍生物中提取的纳米结构黄烷酮制剂（FF）的开发和表征，通过对 进行结构修饰，作为局部炎症的局部治疗的抗炎候选物。对 FF 进行了理化性质表征，并研究了其在大鼠模型中的释放、渗透和抗炎功效。FF 显示出持续的药物释放，并显示出在人皮肤上缓慢的药物渗透。FF 与标准制剂相比减轻了炎症。FF 可作为在皮肤上输送和控制黄烷酮释放的有效系统，并且先导分子 的化学修饰提高了功效。
