Takashina T, Ono M, Kanda Y, Sagae S, Hayakawa O, Ito E
Department of Obstetrics and Gynecology, Sapporo Medical College, Hokkaido, Japan.
Acta Cytol. 1988 Mar-Apr;32(2):159-62.
The clinical significance of cytologic examination was studied in 114 patients with ovarian cancer who had received preoperative cytologic examinations. The overall positive rate of the cytologic examinations was 26.3% (30 of 114): 22 (19.3%) of the 114 cases had positive cervicovaginal smears while 13 of 31 endometrial aspiration smears (41.9%) were positive. The positive rate was not related to the volume of ascites but rather to its presence or absence. Thus, if ascites was observed, the positive rate was about 2.1 times higher than if it was absent. In two of four cases of ovarian cancer with no endometrial invasion but a positive cytologic examination of ascitic fluid, fallopian tube specimens contained cancer cells; this suggests that ovarian cancer cells may reach the cervix and/or vagina by passing through the fallopian tube, particularly if ascites is present. Since cytologic examination, especially of endometrial aspiration smears, shows a high positive rate if ovarian cancer cells are observed in the abdominal cavity, cytology should be used as an important ancillary method for the assessment of ovarian cancer.
对114例接受术前细胞学检查的卵巢癌患者的细胞学检查临床意义进行了研究。细胞学检查的总体阳性率为26.3%（114例中的30例）：114例中有22例（19.3%）宫颈阴道涂片呈阳性，而31例子宫内膜抽吸涂片中13例（41.9%）呈阳性。阳性率与腹水的量无关，而是与其有无有关。因此，如果观察到有腹水，阳性率比没有腹水时高出约2.1倍。在4例无子宫内膜侵犯但腹水细胞学检查呈阳性的卵巢癌病例中，有2例输卵管标本含有癌细胞；这表明卵巢癌细胞可能通过输卵管到达宫颈和/或阴道，特别是如果有腹水存在的话。由于如果在腹腔中观察到卵巢癌细胞，细胞学检查，尤其是子宫内膜抽吸涂片，显示出较高的阳性率，因此细胞学应作为评估卵巢癌的重要辅助方法。
